Acid resistant capsules

Abstract

An acid resistant capsule comprises at least one hard capsule shell, said shell comprising: an enteric polymer having acid groups; a film-forming aid; and an alkaline material, wherein said alkaline material is present in an amount such that said carboxylic acid groups of said enteric polymer have a degree of ionization of less than 15%.

Description

technical field [0001] The present disclosure relates to novel acid-resistant hard capsules suitable for pharmaceutical use, methods for their manufacture and particularly, but not exclusively, the use of such capsules for the oral administration of medicaments, veterinary products, foods and meals to subjects selected from humans or animals supplements. Background technique [0002] Hard drug capsules are usually manufactured by using the dip molding method. In this method, a pin mold is dipped into a water-based film-forming composition. The film is formed by subsequent gelation of the composition adhered to the pin. The film is then dried, peeled from the pins and cut to the desired length. Thereby a capsule cap and a body are obtained, which can then be filled with a substance and are telescopically connected together such that a filled hard drug capsule is obtained. As for patent documents disclosing this method, see eg US5264223, US5756123 and US5756123. [0003] ...

AI Technical Summary

Problems solved by technology

[0010] However, it has been found that although the addition of a neutralizing agent allows effective dissolution of the enteric polymer, thereby benefiting the capsule manufacturing process, the addition of a neutralizing agent may adversely affect the dissolution profile of the capsule, especially when administered with water (usually in its oral form). at the time of application)

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