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Uses of oligostilbene compounds

A technology of stilbene compounds and compounds, which is applied in the field of medical application of oligomeric stilbene compounds, can solve problems such as side effects of patients, achieve the effects of inhibiting fat cell differentiation, improving insulin resistance, and promoting the production of ATP

Active Publication Date: 2022-02-11
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Glucolipid metabolism disorders such as obesity, diabetes, hypertension, hyperlipidemia, and cardiovascular disease are gradually infringing on people's health, and long-term use of traditional therapeutic drugs will have side effects on the patient's body. Therefore, it is urgent to develop a safer and more effective medicines of natural plant origin

Method used

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  • Uses of oligostilbene compounds
  • Uses of oligostilbene compounds
  • Uses of oligostilbene compounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0076] The application of the present invention will be further described through specific examples and experiments below, and the effect of proanthocyanidins on inhibiting cell differentiation will be verified and explained.

[0077] Experimental materials and experimental preparation

[0078] Test samples: including 9 oligostilbene compounds: Vitisin A(F-1), Vitisin B(F-2), VitisinC(F-3), Vitisin D(F-4), Cis-vitisinA(F -5), Resveratrol (T-1), ε-viniferin (T-2), Ampelopsin B (T-3), Hydroxyvitisin D (T-4), are all isolated and purified from the seeds of Sinus cuspidatum, and tested by HPLC The detection purity is above 95%, and its chemical structural formula is as follows:

[0079]

[0080]

[0081] Experimental method: the present invention uses statistical software SPSS 17.0 to carry out the analysis and arrangement of experimental data, and statistical result uses mean ± standard value Indicates that the comparison of the means between the two groups adopts the in...

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Abstract

The invention provides the application of oligostilbene compounds in the preparation of drugs for the prevention and / or treatment of glucose and lipid metabolism disorders, and the activity research of 9 kinds of oligostilbene compounds extracted from the seeds of Sperus chinensis is carried out, and the compounds are verified It can inhibit the differentiation of fat cells, improve insulin resistance, and improve the sensitivity of fat cells to insulin, so as to prepare drugs for preventing or treating obesity, type II diabetes and other metabolic disorders.

Description

technical field [0001] The invention relates to the field of medical applications of oligostilbene compounds, in particular to the use of oligostilbene compounds in the preparation of drugs for diseases related to glucose and lipid metabolism disorders. Background technique [0002] Iris lactea Pall. var. Chinensis (Fisch.) Koidz) is a perennial herbaceous perennial plant of the genus Iris in the family Iridaceae of the Angiospermae phylum. So far, a variety of chemical constituents have been isolated from the seeds of Iris, including flavonoids, benzoquinones, and oligostilbenes. Modern pharmacology has studied the main active ingredients in Iris, and found that Iris has a variety of pharmacological activities, such as radiosensitization, anti-radiation, immunity enhancement, anti-fertility, and anti-implantation effects. However, in recent years, the research on the chemical constituents and pharmacological effects of Iris is mostly limited to the radiation-sensitizing ef...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/343A61K31/05A61P3/04A61P3/06A61P3/10A61P9/12A61P9/00A61P3/00A61P5/50
CPCA61P3/00A61P3/04A61P3/06A61P3/10A61P5/50A61P9/00A61P9/12A61K31/05A61K31/343
Inventor 王洪伦铁芳芳栾广祥
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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