Application of oligomeric stilbene compounds

A stilbene compound and compound technology are applied in the field of medical use of oligomeric stilbene compounds, and can solve problems such as side effects of patients and the like

Active Publication Date: 2019-04-23
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Glucolipid metabolism disorders such as obesity, diabetes, hypertension, hyperlipidemia, and cardiovascular disease are gradually infringing on people's health, and long-term use of traditional therapeutic drugs will have side effects on the patient's body. Therefore, it is urgent to develop a safer and more effective medicines of natural plant origin

Method used

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  • Application of oligomeric stilbene compounds
  • Application of oligomeric stilbene compounds
  • Application of oligomeric stilbene compounds

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0076] The application of the present invention will be further described through specific examples and experiments below, and the effect of proanthocyanidins on inhibiting cell differentiation will be verified and explained.

[0077] Experimental materials and experimental preparation

[0078] Test samples: including 9 oligostilbene compounds: Vitisin A(F-1), Vitisin B(F-2), VitisinC(F-3), Vitisin D(F-4), Cis-vitisinA(F -5), Resveratrol (T-1), ε-viniferin (T-2), Ampelopsin B (T-3), Hydroxyvitisin D (T-4), are all isolated and purified from the seeds of Sinus cuspidatum, and tested by HPLC The detection purity is above 95%, and its chemical structural formula is as follows:

[0079]

[0080]

[0081] Experimental method: the present invention uses statistical software SPSS 17.0 to carry out the analysis and arrangement of experimental data, and statistical results use mean ± standard value Indicates that the comparison of the means between the two groups adopts the in...

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Abstract

The invention provides application of oligomeric stilbene compounds in preparing medicine for preventing and/or treating glucose and lipid metabolism disorder. By extracting the nine oligomeric stilbene compounds from iris lacteal seeds for activity research, it is proved that the compounds can inhibit adipocyte differentiation, improve the insulin resistance and improve the sensitivity of adipocyte to insulin, so that the compounds are used for preparing the medicine for preventing or treating obesity, type II diabetes and other metabolic disorders.

Description

technical field [0001] The invention relates to the field of medical applications of oligostilbene compounds, in particular to the use of oligostilbene compounds in the preparation of drugs for diseases related to glucose and lipid metabolism disorders. Background technique [0002] Iris lactea Pall. var. Chinensis (Fisch.) Koidz) is a perennial herbaceous perennial plant of the genus Iris in the family Iridaceae of the Angiospermae phylum. So far, a variety of chemical constituents have been isolated from the seeds of Iris, including flavonoids, benzoquinones, and oligostilbenes. Modern pharmacology has studied the main active ingredients in Iris, and found that Iris has a variety of pharmacological activities, such as radiosensitization, anti-radiation, immunity enhancement, anti-fertility, and anti-implantation effects. However, in recent years, the research on the chemical constituents and pharmacological effects of Iris is mostly limited to the radiation-sensitizing ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61K31/05A61P3/04A61P3/06A61P3/10A61P9/12A61P9/00A61P3/00A61P5/50
CPCA61P3/00A61P3/04A61P3/06A61P3/10A61P5/50A61P9/00A61P9/12A61K31/05A61K31/343
Inventor 王洪伦铁芳芳栾广祥
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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