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A kind of antibacterial hybrid nano flower hemostatic material and preparation method thereof

A technology of hemostatic materials and nanoflowers, applied in the field of medical materials, can solve problems such as poor adhesion, easy exothermic burning of skin tissue, and no antibacterial activity

Active Publication Date: 2021-06-08
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In order to solve the problems of the existing inorganic mesoporous hemostatic materials, such as easy exothermic burning of skin tissue, poor adhesion and no antibacterial activity, the present invention provides an antibacterial hybrid nanoflower hemostatic material and a preparation method thereof

Method used

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  • A kind of antibacterial hybrid nano flower hemostatic material and preparation method thereof
  • A kind of antibacterial hybrid nano flower hemostatic material and preparation method thereof
  • A kind of antibacterial hybrid nano flower hemostatic material and preparation method thereof

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Embodiment 1

[0022] In this embodiment, the preparation method of the antibacterial hybrid nano flower blood material is carried out according to the following steps:

[0023] Step (1) taking by weighing chitosan with a deacetylation degree of 85% is dissolved in 1wt% acetic acid aqueous solution to obtain a chitosan aqueous solution with a concentration of 1 mg / mL; using distilled water to prepare a sodium tripolyphosphate aqueous solution with a concentration of 150 mg / mL; Use distilled water to prepare a calcium chloride aqueous solution with a concentration of 100 mM;

[0024] Step (2) Add the sodium tripolyphosphate aqueous solution prepared in step (1) dropwise into the chitosan aqueous solution gradually, control the volume ratio of the sodium tripolyphosphate aqueous solution / chitosan aqueous solution to 30 / 70, and stir at 25°C Incubate for 10 min to obtain nanocomposite suspension;

[0025] Step (3) gradually add the nanocomposite suspension obtained in step (2) dropwise in the c...

Embodiment 2

[0030] In this embodiment, the preparation method of the antibacterial hybrid nano flower blood material is carried out according to the following steps:

[0031] Step (1) taking by weighing chitosan with a deacetylation degree of 75% is dissolved in 1.5wt% acetic acid aqueous solution to obtain a chitosan aqueous solution with a concentration of 2 mg / mL; use distilled water to prepare a sodium tripolyphosphate aqueous solution with a concentration of 100 mg / mL ; Use distilled water to prepare a calcium chloride aqueous solution with a concentration of 80mM;

[0032] Step (2) Add the sodium tripolyphosphate aqueous solution prepared in step (1) dropwise into the chitosan aqueous solution gradually, control the volume ratio of the sodium tripolyphosphate aqueous solution / chitosan aqueous solution to 40 / 60, and stir at 28°C Incubate for 20 min to obtain nanocomposite suspension;

[0033] Step (3) gradually add the nanocomposite suspension obtained in step (2) dropwise in the ca...

Embodiment 3

[0038] In this embodiment, the preparation method of the antibacterial hybrid nano flower blood material is carried out according to the following steps:

[0039] Step (1) take by weighing chitosan that deacetylation degree is 80% and dissolve in 2.5wt% acetic acid aqueous solution, obtain the chitosan aqueous solution of concentration 3mg / mL; Use distilled water preparation concentration to be the sodium tripolyphosphate aqueous solution of 200mg / mL ; Use distilled water to prepare a calcium chloride aqueous solution with a concentration of 150mM;

[0040] Step (2) Add the sodium tripolyphosphate aqueous solution prepared in step (1) dropwise into the chitosan aqueous solution gradually, control the volume ratio of the sodium tripolyphosphate aqueous solution / chitosan aqueous solution to 35 / 65, and stir at 15°C Incubate for 15 minutes to obtain nanocomposite suspension;

[0041] Step (3) gradually add the nanocomposite suspension obtained in step (2) dropwise in the calcium ...

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Abstract

The invention discloses an antibacterial hybrid nano flower hemostatic material and a preparation method thereof. The method first utilizes the ordered formation of phosphate and calcium ions on the surface of sodium tripolyphosphate (TPP)-chitosan (CS) nanocomposites. Hybrid nanoflowers were prepared by self-assembly, and then a mussel-like polydopamine coating was constructed on its surface, and silver nanoparticles were generated in situ using the reductive properties of polydopamine. The flower-like multi-level structure can provide high specific surface area and high porosity. Combined with the polydopamine coating on the surface, it has ultra-high hydrophilicity and excellent tissue adhesion, and can quickly absorb water in blood and increase platelet concentration. , The hemostatic performance is significantly improved without generating too much heat. At the same time, polydopamine is directly reduced to generate silver nanoparticles on the surface of nanoflowers in situ, which endows the material with high-efficiency antibacterial effect, and reduces bleeding wound infection while efficiently hemostasis.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and relates to a hemostatic material and a preparation method thereof, in particular to an antibacterial hybrid nanoflower hemostatic material and a preparation method thereof. Background technique [0002] Massive bleeding caused by local wars, natural disasters, traffic accidents, and surgery will seriously threaten the lives of the injured. Therefore, the development of rapid and effective hemostatic agents to control the bleeding at the initial stage of injury has always been a key challenge in wound treatment. At present, hemostatic materials mainly include sponge, fabric, non-woven fabric, hydrogel and powder materials. Powdered hemostatic agent has a good effect due to its advantages of portability, simple and convenient use, and high degree of fit to the wound. At present, the most commonly used inorganic powdery hemostatic materials are zeolite and clay, among which the most c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/04A61L24/02A61L24/00
Inventor 李纪伟刘尚鹏陈韶娟马建伟
Owner QINGDAO UNIV
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