A breast cancer Ki67/ER/PR nuclear staining cell counting method based on staining separation

A technology for cell counting and breast cancer, applied in computing, image analysis, image data processing, etc., can solve the problems of time-consuming and laborious, subjectivity error of accuracy, etc. Effect
CN109712142AActive Publication Date: 2019-05-03SHANDONG COMP SCI CENTNAT SUPERCOMP CENT IN JINAN
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
SHANDONG COMP SCI CENTNAT SUPERCOMP CENT IN JINAN
Publication Date
2019-05-03

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Abstract

The invention discloses a breast cancer Ki67 / ER / PR nuclear staining cell counting method based on staining separation. The method comprises the steps that firstly, a breast cancer pathological sectionimage is dyed and separated, an image IH based on an H coloring agent and an image IDAB based on a DAB color developing agent are obtained, then the influence of intercellular cytoplasm is eliminatedthrough filtering, and an image IH, filterd, IDAB and filterd are obtained; secondly, counting the negative cells according to IH and filterd, counting strong positive, middle positive and weak positive cells according to IDAB, filterd and the brightness map VDAB of the IH and filterd, and finally obtaining the number of the negative cells, the number of the positive cells and the number of the positive cells (divided into strong positive, middle positive and weak positive) and the probability of occupying the total number of the cells. According to the breast cancer nuclear staining cell counting method based on staining separation, cell counting can be rapidly and effectively achieved, doctors are assisted in work, the workload of the doctors is reduced, and meanwhile the calculation accuracy is guaranteed.
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Description

technical field

[0001] The invention relates to a method for counting breast cancer Ki67 / ER / PR nuclear staining cells, more specifically, a method for counting breast cancer Ki67 / ER / PR nuclear staining cells based on staining separation. Background technique

[0002] According to the national cancer data compiled by the National Cancer Center and the Bureau of Disease Control and Prevention of the Ministry of Health in 2018, the incidence of breast cancer has ranked first in the incidence of female malignant tumors in the country for two consecutive years. The global incidence of breast cancer in women has been on the rise since the late 1970s. China is not a country with a high incidence of breast cancer, but it should not be optimistic. In recent years, the growth rate of the incidence of breast cancer in my country is 1 to 2 percentage points higher than that of countries with a high incidence. For primary breast cancer, immunohistochemical typing is performed internatio...

Claims

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