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Filling method of Ibuprofen oral suspension

A technology of suspension and material liquid, which is applied in the field of pharmaceuticals, can solve problems such as viscosity, difficulty in filling and sealing precise control of filling volume, and achieve the effect of accurate filling volume, not easy to leak, and convenient for storage and transportation

Inactive Publication Date: 2019-05-10
YANGZHOU YIYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, the suspension-type medicine is often relatively viscous, which makes it difficult to fill and seal during the production process, especially to accurately control the filling volume. Therefore, it is urgent to invent a method to solve the above technical problems

Method used

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  • Filling method of Ibuprofen oral suspension
  • Filling method of Ibuprofen oral suspension
  • Filling method of Ibuprofen oral suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Filling of ibuprofen suspension

[0025] (1) Turn on the circulation pump of the storage tank, keep the temperature of the feed liquid at 20°C, and make it circulate;

[0026] (2) Detect the relative density ρ of feed liquid, weigh the average weight M1 of the bottle, calculate the filling capacity of every bottle of medicinal liquid according to the following formula: M2=ρ*V+M1;

[0027] Among them, V is the marked filling volume of each bottle of liquid medicine;

[0028] (3) Turn on the filling machine, adjust the filling capacity according to M2, control the temperature of the feed liquid to 20°C, and the flow rate of the feed liquid in the main filling pipeline to be 3L / min; the inner diameter of the main filling pipeline is 10cm;

[0029] (4) Discard the initial feed liquid, fill, and mark the filling amount ≤ control average filling amount ≤ marked filling amount * (1+10%).

[0030] The detection method of relative density is: take a clean, dry and precisely we...

Embodiment 2

[0035] Filling of ibuprofen suspension

[0036] (1) Turn on the circulation pump of the storage tank, keep the temperature of the feed liquid at 35°C, and make it circulate;

[0037] (2) Detect the relative density ρ of feed liquid, weigh the average weight M1 of the bottle, calculate the filling capacity of every bottle of medicinal liquid according to the following formula: M2=ρ*V+M1;

[0038] Among them, V is the marked filling volume of each bottle of liquid medicine;

[0039] (3) Turn on the filling machine, adjust the filling capacity according to M2, control the temperature of the feed liquid to be 30°C, and the flow rate of the feed liquid in the main filling pipeline is 6L / min; the inner diameter of the main filling pipeline is 30cm;

[0040] (4) Discard the initial feed liquid, fill, and mark the filling amount ≤ control average filling amount ≤ marked filling amount * (1+10%).

[0041] The detection method of relative density is: take a clean, dry and precisely we...

Embodiment 3

[0047] Filling of ibuprofen suspension

[0048] (1) Turn on the circulation pump of the storage tank, keep the temperature of the feed liquid at 25°C, and make it circulate;

[0049] (2) Detect the relative density ρ of feed liquid, weigh the average weight M1 of the bottle, calculate the filling capacity of every bottle of medicinal liquid according to the following formula: M2=ρ*V+M1;

[0050] Among them, V is the marked filling volume of each bottle of liquid medicine;

[0051] (3) Turn on the filling machine, adjust the filling capacity according to M2, control the temperature of the feed liquid to be 25°C, and the flow rate of the feed liquid in the main filling pipeline is 5L / min; the inner diameter of the main filling pipeline is 20cm;

[0052] (4) Discard the initial feed liquid, fill, and mark the filling amount ≤ control average filling amount ≤ marked filling amount * (1+10%).

[0053] The detection method of relative density is: take a clean, dry and precisely we...

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Abstract

The invention relates to a filling method of Ibuprofen oral suspension. The method comprises the steps that a storage kettle circular pump is started, the feed liquid temperature is kept between 20 to35 DEG C, and feed liquid circularly flows; secondly, the relative density Rho of the feed liquid is detected, the average weight M1 of a bottle is weighed, and according to the following formula M2=Rho*V+M1, the loading quantity of feed liquid in each bottle is calculated; thirdly, a filling machine is started, and the loading quantity is adjusted according to M2; and fourthly, initial feed liquid is discarded, and filling is carried out. The Ibuprofen oral suspension prepared through the method is accurate in loading amount, not prone to leakage and convenient to store and transport.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a filling method of ibuprofen suspension. Background technique [0002] Ibuprofen Suspension (Ibuprofen Suspension) is a drug approved for marketing in the People's Republic of China, and it is an antipyretic and analgesic non-prescription drug. The quality control of the ibuprofen suspension is carried out according to the national drug standard YBH05042010 of the Food and Drug Administration of the People's Republic of China. [0003] Every 100mL of ibuprofen suspension contains 2g of ibuprofen. Ibuprofen is an antipyretic and analgesic, non-steroidal anti-inflammatory drug. The molecular formula of ibuprofen is C13H18O2, CAS accession number: 15687-27-1. This product reduces the synthesis of prostaglandins by inhibiting cyclooxygenase, and produces analgesic and anti-inflammatory effects; it has an antipyretic effect through the hypothalamic thermoregulatory center. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B67C3/00
Inventor 吉宏赵莉
Owner YANGZHOU YIYANG PHARMA