Alzheimer's disease brain network feature extraction method based on a continuous homology technology

A network feature and brain network technology, applied in the field of brain network analysis, can solve the problems of poor calculation accuracy, lack of accuracy of functional network, no clear selection rules, etc., and achieve the effect of reducing the computational burden.

Active Publication Date: 2019-05-17
HARBIN ENG UNIV
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Problems solved by technology

But this method mainly has two deficiencies: (1) threshold selection problem
The threshold value of the graph theory method is selected by artificial selection strategy, and there is no clear selection rule, and the functional network constructed based on a selected threshold value lacks accuracy; (2) the basis of the graph theory method is to abstract the network into a pairwise interconnection mode, but this method has a large computational load and is only suitable for large-scale brain region segmentation methods. When faced with small and medium-scale brain network partition strategies, it shows disadvantages such as poor calculation accuracy and poor stability. The research must go deep into the microscopic field, and the graph theory method has gradually shown its shortcomings

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  • Alzheimer's disease brain network feature extraction method based on a continuous homology technology
  • Alzheimer's disease brain network feature extraction method based on a continuous homology technology
  • Alzheimer's disease brain network feature extraction method based on a continuous homology technology

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Embodiment 1

[0028] combine figure 1 , the realization of the present invention comprises the following steps:

[0029] (1) The diagnosis of Alzheimer's disease requires a functional magnetic resonance scan for further diagnosis. Extract the resting state functional magnetic resonance data of the patient. The data imaging adopts a 3T magnetic resonance scanner, the deflection angle is 77°, the repetition time TR is 2m, the recovery time is 32ms, the imaging matrix is ​​64×64, and the field of view FOV is 256×256mm 2 , the number of scanning layers is 34, the volume imaging is 150, and the voxel thickness is 4mm. SPM8 is used to complete time layer correction, head movement correction, standardization, smoothing and other processing, and DPABI is used to complete covariate removal and local consistency verification.

[0030](2) Select the AAL (Anatomical Automatic Labeling) brain network segmentation template, divide the brain into 90 functionally specific local ROI brain regions, abstrac...

Embodiment 2

[0050] Step 1: Data preprocessing. Magnetic resonance scans were performed on patients with Alzheimer's disease to obtain resting-state functional magnetic resonance data. And preprocessing work such as time layer correction, head motion correction, standardization, smoothing and removal of covariates is performed on the obtained magnetic resonance time series data.

[0051] Step 2: Brain network division. Select the brain region segmentation template, physically segment the whole brain map, and determine the nodes in the brain network connection. For the brain region segmentation results of each node, extract the preprocessed time series data in step 1, and perform overall mean value processing on the time series of each voxel in each brain region to obtain a set of time series values.

[0052] Step 3: Brain network construction. Using the mean value of the time series of each brain region node obtained in step 2, do a temporal correlation analysis between different brain ...

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Abstract

The invention discloses an Alzheimer's disease brain network feature extraction method based on a continuous coherence technology, and belongs to the technical field of brain network analysis. According to the invention, through data preprocessing, brain network division, brain network construction, continuous coherent brain network filtering flow construction, continuous interval data statisticalanalysis and Alzheimer's disease brain network feature extraction, brain network feature extraction of a patient is realized. By constructing the multi-scale brain network with the variable thresholdvalue, the threshold value selection problem in a graph theory method is avoided, wherein the continuous feature discovery mechanism of the network complex flow can effectively reduce the calculationburden, and is an effective brain network analysis technology. The continuous homology theory is applied to the field of brain analysis of patients suffering from Alzheimer's disease, the brain mechanism is researched, the brain network connection characteristics of diseases are discovered, and the method is an innovative research idea and has important significance for early diagnosis, drug development and diagnosis and treatment scheme formulation of Alzheimer's disease.

Description

technical field [0001] The invention belongs to the technical field of brain network analysis, and in particular relates to a feature extraction method for Alzheimer's disease brain network based on continuous coherence technology. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD) is a common neurological disease in the elderly, which mainly affects the central nervous system in the brain of the elderly, causing degenerative changes. When patients have obvious clinical symptoms of Alzheimer's disease, most of the disease has entered the advanced stage and cannot be treated at all. Therefore, the early diagnosis and intervention of Alzheimer's disease has become the focus of most researches. [0003] Research on the early diagnosis of Alzheimer's disease mainly focuses on the extraction of marker features, including neuropsychological features and biological features. Neuropsychological characteristics, oriented to the diagnosis of AD with clinical...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/00G06T7/10
Inventor 李金边晨源梁洪鲍佩华何兵兰海青王铮李延召罗浩然高岳
Owner HARBIN ENG UNIV
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