Method for extracting flavonoid glycoside compound from epimedium

A technology of flavonoid glycosides and epimedium, applied in the direction of alkali metal compounds, chemical instruments and methods, alkali metal oxides/hydroxides, etc., to achieve the effect of strengthening the ultrasonic effect, safe use, and low vapor pressure

Inactive Publication Date: 2019-05-31
浦江县美泽生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to address the problems existing in the prior art, to provide a method for extracting flavonoid glycosides in Epimedium using a deep eutectic solvent, and using collagen fiber separation materials to separate and purify, effectively improving the flavonoid glycosides Excellent extraction efficiency, separation purity and yield; mild extraction conditions, easy operation, and at the same time solve the problems existing in the use of flammable and explosive organic solvents in the existing extraction technology of flavonoid glycosides

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The method for extracting flavonoid glycosides from Epimedium, using Epimedium as a raw material, utilizing a deep eutectic solvent, especially the solvent formed by benzyltriethylammonium chloride and polyhydric alcohols as an extractant, using water as a The diluent of the system viscosity extracts the flavonoid glycosides under the strengthening of ultrasound; and uses the collagen fiber separation material for separation and purification;

[0029] Specifically include the following steps:

[0030] 1) crush the dried Epimedium, pass through a 80-mesh sieve, add a deep eutectic solvent, then add zinc isooctanoate and zinc methacrylate, and extract under ultrasonic conditions to obtain an extract of flavonoid glycosides;

[0031] The above-mentioned deep eutectic solvent is a mixture of benzyltriethylammonium chloride, glycerin and water; the volume ratio of the three is: 1:1.2:0.8;

[0032] The preparation method of the deep eutectic solvent is: first mix and stir be...

Embodiment 2

[0043] The method for extracting flavonoid glycosides from Epimedium, using Epimedium as a raw material, utilizing a deep eutectic solvent, especially the solvent formed by benzyltriethylammonium chloride and polyhydric alcohols as an extractant, using water as a The diluent of the system viscosity extracts the flavonoid glycosides under the strengthening of ultrasound; and uses the collagen fiber separation material for separation and purification;

[0044] Specifically include the following steps:

[0045] 1) crush the dried Epimedium, pass through a 80-mesh sieve, add a deep eutectic solvent, then add zinc isooctanoate and zinc methacrylate, and extract under ultrasonic conditions to obtain an extract of flavonoid glycosides;

[0046] Above-mentioned deep eutectic solvent is the mixture of benzyltriethylammonium chloride, butanediol and water; The volume ratio of the three is: 1:3:1;

[0047] The preparation method of the deep eutectic solvent is as follows: first, mix and...

Embodiment 3

[0056] The method for extracting flavonoid glycosides from Epimedium, using Epimedium as a raw material, utilizing a deep eutectic solvent, especially the solvent formed by benzyltriethylammonium chloride and polyhydric alcohols as an extractant, using water as a The diluent of the system viscosity extracts the flavonoid glycosides under the strengthening of ultrasound; and uses the collagen fiber separation material for separation and purification;

[0057] Specifically include the following steps:

[0058] 1) crush the dried Epimedium, pass through a 100-mesh sieve, add a deep eutectic solvent, then add zinc isooctanoate and zinc methacrylate, and extract under ultrasonic conditions to obtain an extract of flavonoid glycosides;

[0059] Above-mentioned deep eutectic solvent is the mixture of benzyltriethylammonium chloride, sorbitol and water; The volume ratio of the three is: 1:3:2;

[0060] The preparation method of the deep eutectic solvent is: first mix and stir benzylt...

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PUM

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Abstract

The invention provides a method for extracting a flavonoid glycoside compound from epimedium, and belongs to the field of extracting traditional Chinese medicine. The extraction method includes usingthe epimedium as a raw material, utilizing a deep eutectic solvent, especially a solvent formed by benzyl triethyl ammonium chloride and polyhydric alcohols as an extracting agent and utilizing wateras a diluent for lowering the system viscosity to extract the flavonoid glycoside compound under ultrasonic enhancement; utilizing a collagen fiber separating material for separation and purification;adding zinc isooctanoate and zinc methacrylate in the solvent to enhance ultrasonic extraction. The method is mild in extracting condition, simple to operate and high in flavonoid glycoside compoundextracting efficiency, separation purity and yield. The problem in the prior art that flammable explosive organic solvents need to be used is solved.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine extraction, in particular to a method for extracting flavonoid glycosides from Epimedium. Background technique [0002] Epimedium is a plant belonging to the family Berberidaceae Epimedium brevicornum Maxim, Epimedium sagittatum (Sieb.et Zucc.) Maxim., Epimedium pubescens Maxim. or Epimedium pubescens Maxim. The dry leaves of Epimedium koreanum Nakai are harvested when the lotus leaves are in full bloom in summer and autumn. Epimedium has the effects of strengthening yang and tonifying kidney, expelling wind and dampness, and strengthening bones and tendons. It is a traditional Chinese medicine for tonifying deficiency and strengthening yang. At present, various chemical components have been isolated from Epimedium, and flavonoid glycosides are components with higher content in Epimedium, and are currently considered to be one of the active ingredients in Epimedium extract. Pharmacolo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08B01J20/24B01J20/28
Inventor 谢雨欣
Owner 浦江县美泽生物科技有限公司
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