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Method of simultaneous rapid analysis on perfluorinate chemicals, phenolic chemicals and estrogen in blood

A technology for rapid analysis of phenolic compounds, applied in the field of analytical chemistry, can solve the problems of affecting analysis efficiency, long analysis time, high analysis cost, etc., and achieve the effect of improving analysis efficiency

Inactive Publication Date: 2019-06-04
FUDAN UNIV
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Problems solved by technology

[0005] The purpose of the present invention is to provide a kind of blood perfluorinated compound, phenolic Simultaneous rapid analysis method of compound and estrogen, to achieve simultaneous analysis of the shortcomings of the three types of compounds, improve analysis efficiency

Method used

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  • Method of simultaneous rapid analysis on perfluorinate chemicals, phenolic chemicals and estrogen in blood
  • Method of simultaneous rapid analysis on perfluorinate chemicals, phenolic chemicals and estrogen in blood
  • Method of simultaneous rapid analysis on perfluorinate chemicals, phenolic chemicals and estrogen in blood

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Embodiment 1

[0020] Five common PFCs, two phenolic compounds and three estrogens were used as target compounds to demonstrate the detection limit, linear range, precision and accuracy of the analytical method of the present invention.

[0021] 1 Materials and methods

[0022] 1.1 Instruments and reagents

[0023] The ACQUITY ultra-high performance liquid chromatograph of Waters Company in the United States is connected in series with a SYNAPTG2 high-resolution quadrupole / time-of-flight mass spectrometer and a 60mg / 3ml HLB solid-phase extraction column. The 12-position solid-phase extraction device and the OA-SYS-5085 nitrogen blowing instrument were purchased from Supelco Company of the United States and Organomation Associates Company of the United States, respectively. Five PFCs standards (perfluorooctanoic acid (PFOA), perfluorooctanoic acid (PFOS), perfluorohexanesulfonic acid (PFHxS), perfluoroundecanoic acid (PFUdA) and perfluorononanoic acid (PFNA)), two One phenol (bisphenol A (B...

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Abstract

The invention belongs to the technical field of analytical chemistry, and relates to a method of realizing simultaneous rapid analysis on perfluorinate chemicals, phenolic chemicals and estrogen in blood, so as to solve the defects of expensive analysis, long analysis time and affected analysis efficiency when three different analysis methods are required in current analysis to detect blood and urine of the same research object. After beta-glucuronidase, acid or alkali is adopted to hydrolyze a blood sample, the blood sample is purified by solid phase extraction, the PFCs, the phenolic chemicals and the estrogen in the blood are simultaneously detected by using liquid chromatography tandem mass spectrometry, and the analysis results show that through one-time sample pretreatment and chromatographic analysis, the PFCs, the phenolic chemicals and the estrogen in the blood are analyzed simultaneously, the defects of simultaneously analyzing the three kinds of chemicals currently can be obviously solved, and the analysis efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of analytical chemistry, and in particular relates to a simultaneous rapid analysis method capable of realizing perfluorinated compounds, phenolic compounds and estrogen in blood. Background technique [0002] The prior art discloses that both perfluorinated chenimcals (PFCs) and phenolic compounds are important plastic monomers and are widely used in industrial and civil fields. The former is a typical persistent environmental pollutant, while the latter is a typical non-persistent environmental pollutant. More and more studies have found that PFCs and phenolic compounds have endocrine disrupting effects and can cause endocrine-related metabolic diseases. By detecting blood or urine, epidemiological studies have confirmed that the population is widely exposed to PFCs and phenolic compounds, and it has also been observed that exposure to PFCs and phenolic compounds is related to changes in estrogen homeosta...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
Inventor 王和兴何更生姜庆五
Owner FUDAN UNIV
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