Method of simultaneous rapid analysis on perfluorinate chemicals, phenolic chemicals and estrogen in blood

A technology for rapid analysis of phenolic compounds, applied in the field of analytical chemistry, can solve the problems of affecting analysis efficiency, long analysis time, high analysis cost, etc., and achieve the effect of improving analysis efficiency
CN109839451AInactive Publication Date: 2019-06-04FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
FUDAN UNIV
Publication Date
2019-06-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of analytical chemistry, and relates to a method of realizing simultaneous rapid analysis on perfluorinate chemicals, phenolic chemicals and estrogen in blood, so as to solve the defects of expensive analysis, long analysis time and affected analysis efficiency when three different analysis methods are required in current analysis to detect blood and urine of the same research object. After beta-glucuronidase, acid or alkali is adopted to hydrolyze a blood sample, the blood sample is purified by solid phase extraction, the PFCs, the phenolic chemicals and the estrogen in the blood are simultaneously detected by using liquid chromatography tandem mass spectrometry, and the analysis results show that through one-time sample pretreatment and chromatographic analysis, the PFCs, the phenolic chemicals and the estrogen in the blood are analyzed simultaneously, the defects of simultaneously analyzing the three kinds of chemicals currently can be obviously solved, and the analysis efficiency is improved.
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Description

technical field

[0001] The invention belongs to the technical field of analytical chemistry, and in particular relates to a simultaneous rapid analysis method capable of realizing perfluorinated compounds, phenolic compounds and estrogen in blood. Background technique

[0002] The prior art discloses that both perfluorinated chenimcals (PFCs) and phenolic compounds are important plastic monomers and are widely used in industrial and civil fields. The former is a typical persistent environmental pollutant, while the latter is a typical non-persistent environmental pollutant. More and more studies have found that PFCs and phenolic compounds have endocrine disrupting effects and can cause endocrine-related metabolic diseases. By detecting blood or urine, epidemiological studies have confirmed that the population is widely exposed to PFCs and phenolic compounds, and it has also been observed that exposure to PFCs and phenolic compounds is related to changes in estrogen homeosta...

Claims

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