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Application of miR-327 inhibitor and/or FGF10 accelerant to medicine for preventing and/or treating diabetes

1. The technology of mir-327 and inhibitors, which is applied in the field of medicine, can solve the problems of liver and other organ damage and unfavorable health

Active Publication Date: 2019-06-18
义慧科技(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, among the commercially available drugs for the prevention and treatment of diabetes, most of them are based on the principle of stimulating insulin secretion and reducing the absorption of glucose from the gastrointestinal tract to control diabetes, but long-term use of these drugs will cause liver and other organs Injuries are bad for your health

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  • Application of miR-327 inhibitor and/or FGF10 accelerant to medicine for preventing and/or treating diabetes
  • Application of miR-327 inhibitor and/or FGF10 accelerant to medicine for preventing and/or treating diabetes
  • Application of miR-327 inhibitor and/or FGF10 accelerant to medicine for preventing and/or treating diabetes

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Embodiment Construction

[0055] The following descriptions are preferred implementations of the embodiments of the present invention. It should be pointed out that those skilled in the art can make some improvements and modifications without departing from the principles of the embodiments of the present invention. These improvements And retouching are also regarded as the scope of protection of the embodiments of the present invention.

[0056] Experimental group: A customized LNA inhibitor probe that antagonizes miR-327 is selected as the miR-327 inhibitor (the miR-327 inhibitor can target and inhibit miR-327, and its sequence is complementary to the nucleotide sequence of miR-327 wherein the nucleotide sequence of miR-327 includes ACUUGAGGGGCAUGAGGAU). Twelve 8-week-old female C57BL / 6 mice were placed under thermoneutral conditions (30°C), and the above-mentioned miR-327 inhibitor was injected subcutaneously once a week at a dose of 8 mg / kg, and then given cold (4°C) or drug stimulation (such as β...

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Abstract

The invention provides novel application of an miR-327 inhibitor and / or an FGF10 accelerant, specifically application to preparation of a medicine for preventing and / or treating diabetes. The miR-327inhibitor and the FGF10 accelerant both can promote addition of FGF10 in matrix cell compositions of adipose tissue, promote adipose cell precursor of the matrix cell compositions to differentiate tobrown adipose cells, promote blood glucose consumption and improve insulin sensitivity, so that the purpose of preventing and / or treating diabetes is achieved. The invention further provides the medicine for preventing and / or treating diabetes. The medicine comprises one or more of the miR-327 inhibitor and the FGF10 accelerant and pharmaceutically acceptable carriers.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of miR-327 inhibitors and / or FGF10 promoters in medicines for preventing and / or treating diabetes. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. Diabetes is generally caused by genetic factors or environmental factors, among which overeating, reduced physical activity and obesity are the most important environmental factors for type Ⅱ diabetes. Over time, diabetes can damage the heart, blood vessels, eyes, kidneys and nerves. The risk of heart attack and stroke in adults with diabetes increases by two to three times; diabetic retinopathy is the main cause of blindness, it is the result of long-term accumulation of damage to small blood vessels in the retina, 2.6% of blindness can be attributed to diabetes; It...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K38/18A61K31/7105A61P3/10
Inventor 杨云龙曹义海
Owner 义慧科技(深圳)有限公司
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