Absorbable hemostasis bone wax and preparation method thereof

Abstract

The invention discloses absorbable hemostasis bone wax and a preparation method thereof. The bone wax is prepared from a degradable material, can be metabolized or absorbed by the body after being implanted for a period of time and does not stay in the body for a long time, so that probability of foreign matter infection is lowered; by adding of thrombin as a hemostasis factor, an immediate hemostasis effect is improved; due to high adhesion with a bone wound, a continuous hemostasis effect can be achieved. The absorbable hemostasis bone wax comprises a base material, an auxiliary material, anemulsifying agent and the hemostasis factor. The base material is prepared by mixing any two or more of poly-DL-lactic acid, poly-L-lactic acid, polyglycolic acid, polycaprolactone, polyethylene glycol, polyvinyl alcohol, polyether glycol, polyether triol, polylactic acid, a glycolide-lactide copolymer, a caprolactone lactide copolymer and a caprolactone-glycolide copolymer. The auxiliary material is prepared by mixing any one or two of beta-tricalcium phosphate and hydroxyapatite. The emulsifying agent is prepared by mixing any one or two of sorbitan fatty acid ester and water-soluble cellulose. Thrombin serves as the hemostasis factor.

Description

technical field [0001] The invention relates to medical bone wax, in particular to an absorbable hemostatic bone wax and a preparation method thereof. Background technique [0002] Clinically, the structure of cancellous bone is loose and the blood supply is rich, and the wound bleeding is mostly oozing blood. Cancellous bone wounds bleed continuously or are difficult to stop bleeding completely because the tissue structure of the bone wound is loose, the blood supply is rich and dense sinuses are formed, the vasoconstriction in the tissue is poor, platelets aggregate, and blood clots are difficult to adhere to the bone wound. Bone wound bleeding is difficult to stop bleeding by vasoconstriction, and it is also difficult to stop bleeding by conventional methods such as electrocoagulation, forceps, hemostatic gauze, and gelatin sponge packing during surgery. Bone wax is often used clinically to stop bleeding on cancellous bone wounds. [0003] The principle of bone wax is to...

AI Technical Summary

Problems solved by technology

[0004] In addition, most of the commonly used bone wax used in China is non-degradable. The main components are beeswax, vaseline, etc., which have good softening properties and can be molded after being softened by hand rubbing. , absorption, and will remain in the body as a foreign body for a long time after application

At present, there are many clinical problems in the above-mentioned bone wax: first, the implantation of bone wax as a foreign body reduces the anti-infection ability of the tissue, which increases the risk of postoperative infection; second, it hinders the repair of bone wounds and forms local pain caused by foreign body granulomas , exudate and other symptoms; third, the bonding effect between beeswax and bone is not good, it is not easy to adhere to the bone surface, and it is easy to slip off during the operation

The main problem is that it has certain elasticity, poor ductility, and some unreacted monomers remain, which greatly stimulates human tissues.

[0010] Animal experiments and clinical applications have shown that although these substances have good biocompatibility and degradability, most of them are in the form of powder and gel, which have poor adhesion to wounds, are difficult to operate during surgery, and are easily washed away by blood flow.

In addition, such polymer substitutes still have unresolved practical problems such as expensive raw materials, difficult modification of physical properties, and material safety. Further in-depth research and improvement

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