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Insect specific small molecule toxin and application

A small molecule, specific technology, used in applications, pesticides, animal repellants, etc., to achieve reliable results and strong effects

Active Publication Date: 2019-07-12
HUNAN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, there is no report on the selective effect of these acetylpolyamine small molecules on insect sodium channels

Method used

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  • Insect specific small molecule toxin and application
  • Insect specific small molecule toxin and application
  • Insect specific small molecule toxin and application

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Embodiment Construction

[0029] The invention provides an insect-specific small-molecule toxin, which is a quaternary ammonium-type small-molecule toxin isolated and purified from the crude venom of E. grandina. The relative molecular weight is 674.4647. The nuclear magnetic resonance structure analyzes The molecular formula of the specific small molecule toxin is C 33 h 59 o 5 N 10 , whose structural formula is:

[0030]

[0031] The application of the insect-specific small molecule toxin provided by the present invention in insecticides or in neurobiological reagents and / or medicines, especially when it is used as an insecticide in the manner of blocking or completely blocking insect sodium ion channels application. When the insect-specific small-molecule toxin completely blocks the insect sodium ion channel, the concentration of the insect-specific small-molecule toxin is not more than 10 μmol / L; the half-effective concentration of the insect-specific small-molecule toxin on the insect sodiu...

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Abstract

The invention belongs to the technical field of chemistry and chemical engineering, and relates to insect specific small molecule toxin and application. The insect specific small molecule toxin adoptsquaternary amine small molecule toxin obtained from araneus ventricosus crude toxin through separation and purification, with the relative molecular weight being 674.4647, and magnetic resonance imaging structure analysis shows that the molecular formula of small molecule toxin obtained from the araneus ventricosus crude toxin through separation and purification is C33H59O5N10. The invention provides insect specific small molecule toxin which has selective activity to insects, is little affected by pH, high in action and stable in effect and application.

Description

technical field [0001] The invention belongs to the technical field of chemistry and chemical engineering, and relates to a small-molecule toxin and its application, in particular to an insect-specific small-molecule toxin and its application. Background technique [0002] The large-bellied garden spider (Araneus ventricosus) is a medium-sized spider that feeds on insects, and belongs to the phylum Arthropoda, Araneus, Aranea, Orbidae, and Orb genus in classification. The arachnid is one of the most widely distributed spiders in the world, and its venom contains a large number of toxic components that can anesthetize or kill insects. Explore the structural and functional characteristics of these insect-specific small molecule toxins, and screen out precursor molecules that may be used as neurobiological research tool reagents, drugs and insecticides. At present, there are very few studies on the venom of the lobster spider. Kawai et al. in Japan found that the extract of th...

Claims

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Application Information

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IPC IPC(8): C07D209/18A01N47/44A01P7/04
CPCC07D209/18A01N47/44
Inventor 段志贵刘凯
Owner HUNAN NORMAL UNIVERSITY