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Application of osteocalcin to preparation of medicines for Alzheimer's disease

A technology for Alzheimer's disease and osteocalcin, which is applied in the field of application of osteocalcin in the preparation of Alzheimer's disease drugs, and can solve the problems of lack of research and not bone-specific secretion substances

Pending Publication Date: 2019-07-19
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is a lack of research on the regulation of bone on the central nervous system, and most of them are not bone-specific secretion substances.

Method used

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  • Application of osteocalcin to preparation of medicines for Alzheimer's disease
  • Application of osteocalcin to preparation of medicines for Alzheimer's disease
  • Application of osteocalcin to preparation of medicines for Alzheimer's disease

Examples

Experimental program
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Effect test

Embodiment 1

[0025] (1) OCN intervention

[0026] Firstly, the APP / PS1 mice were intervened by intraperitoneal injection of ucOCN. The entire intervention lasted for 4 weeks, and ucOCN was injected intraperitoneally once a day at a fixed time point, and the doses were 1ug / kg and 10ug / kg, respectively. Therefore, the groups of mice injected intraperitoneally were: WT, WT+10ug / kg OCN, AD, AD+1ug / kg OCN and AD+10ug / kg OCN, 15 in each group, 75 mice in total. The preparation method of ucOCN is to dissolve 1mg of ucOCN powder in 1ml of sterile N.S., divide it evenly and store it in a -80°C refrigerator for later use. It can be diluted to the corresponding concentration with sterile N.S. when used.

[0027] In view of the fact that ucOCN participates in the regulation of a series of physiological functions such as promoting insulin secretion, improving insulin resistance, improving glucose tolerance and blood lipids in the periphery, in order to clarify whether ucOCN directly enters the brain t...

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Abstract

The invention relates to an application of osteocalcin to preparation of medicines for Alzheimer's disease. According to the application, the inventor finds that OCN can improve cognitive impairment and starch fibroid plaque deposition of AD mice, can restrain activation of glial cells, and can adjust and control AKT / mTOR routes, and a new possibility direction and a molecule target point are provided for preparing medicines for preventing and / or treating the Alzheimer's disease.

Description

technical field [0001] The invention belongs to the field of Alzheimer's disease treatment, in particular to the application of osteocalcin in the preparation of Alzheimer's disease medicine. Background technique [0002] The aging process of the body is usually accompanied by different degrees of bone density decline and neurodegeneration. Alzheimer's disease (Alzheimer's disease, AD) is the most common neurodegenerative disease, and it is also the main cause of dementia. patient's quality of life. Epidemiological investigations have shown that AD patients have a higher risk of osteoporosis, and osteoporosis patients also have a higher risk of AD, suggesting that there is a comorbidity between the two. The common feature of primary osteoporosis and AD is that there are no boundaries of geography, race, and socioeconomic status. The incidence of both increases with age, seriously affecting the quality of life of patients, and the task of prevention and treatment is arduous...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61P25/28
CPCA61K38/1709A61P25/28
Inventor 刘建民单畅李胜天侯艳芳王淑敏宁光
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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