Inhalant Formulation Containing Sulfoalkyl Ether Cyclodextrin and Corticosteroid

a technology of sulfoalkyl ether and corticosteroid, which is applied in the field of inhalant formulations containing sulfoalkyl ether cyclodextrin and corticosteroid, can solve the problems of increased cost, inconvenience of needing to prepare medication, and reduced portability, so as to reduce the rate of degradation of corticosteroid, increase the output rate and/or extent of nebulized corticosteroid
US20070202054A1Inactive Publication Date: 2007-08-30CYDEX PHARMA INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
CYDEX PHARMA INC
Publication Date
2007-08-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

An inhalable formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus.
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Description

CROSS-REFERENCE TO EARLIER FILED APPLICATIONS

[0001] The present application is a continuation-in-part of and claims the priority of U.S. application Ser. No. 11 / 479,979 filed Jun. 30, 2006, which is a continuation-in-part of PCT International Application No. PCT / US05 / 00082 filed Dec. 31, 2004, which claims benefit of the filing date of provisional application No. 60 / 533,628 filed Dec. 31, 2003, the disclosures of which are hereby incorporated by reference in their entirety.FIELD OF THE INVENTION

[0002] The present invention relates to methods of and systems for administering formulations of sulfoalkyl ether cyclodextrin and corticosteroid, such as budesonide, by nebulization and inhalation. The invention also relates to methods of treating respiratory diseases or disorders of the air passageways. BACKGROUND OF THE INVENTION

[0003] The delivery of a drug by inhalation allows deposition of the drug in different sections of the respiratory tract, e.g., throat, trachea, bronchi and alv...

Claims

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