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Dengue virus-like particle, antibody against dengue virus, and composition comprising the same

一种类病毒颗粒、登革热病毒的技术，应用在登革热的治疗领域，能够解决使用疫苗功效低等问题

Active Publication Date: 2019-07-23
赵黛瑜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although yellow fever tetravalent dengue vaccine (YFTD) has recently been approved by a few countries, such vaccines have limited use and low vaccine efficacy in previously dengue-infected populations over nine years of age, and there is an urgent need to develop second-generation dengue Vaccines (3,4)

Method used

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  • Dengue virus-like particle, antibody against dengue virus, and composition comprising the same
  • Dengue virus-like particle, antibody against dengue virus, and composition comprising the same
  • Dengue virus-like particle, antibody against dengue virus, and composition comprising the same

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Embodiment Construction

[0028] The envelope (E) protein, which is exposed on the surface of infectious mature virions, is the only target of neutralizing antibodies. During viral replication, newly synthesized immature DENV assembles in the endoplasmic reticulum at neutral pH and acts as a mechanical barrier with the pr portion of the precursor membrane (prM) protein (see figure 1 (A)) would be positioned to cover the fusion loop (FL) of the peptide distal to each E protein of the early fused trimer (5,6). To be fully infectious, the pr moiety must be removed (ie cleaved) by the cellular protease furin during the egress process. However, the maturation process of DENV is considered to be inefficient, and DENV particles are released from infected cells as a heterogeneous population, depending on the degree of cleavage of the membrane (M) protein by prM to the M protein: immature particles Comprising only uncleaved prM protein, partially immature granules contain both prM and M proteins, while fully m...

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Abstract

The present invention is related to a Dengue virus-like particle. Said Dengue virus-like particle exhibits almost-cut pr-M junction and is particularly suitable for producing antibody that recognizesall four types of Dengue virus. The present invention also provides antibody obtained by using said virus-like particle and composition comprising the same.

Description

technical field [0001] The present invention relates to the treatment of dengue fever, especially the antibody and composition for this purpose, and the preparation method thereof. Background technique [0002] Dengue virus (DENV), a member of the Flaviviridae family, is a mosquito-borne pathogen with four distinct serotypes, including DENV-1 to DENV-4 (1). Today, DENV is estimated to infect approximately 390 million cases worldwide each year, causing 96 million cases of clinical manifestations ranging from mild fever to Dengue Hemorrhagic Fever (DHF) or life-threatening Dengue Shock Syndrome (DSS) (2). Although yellow fever tetravalent dengue vaccine (YFTD) has recently been approved by a few countries, such vaccines have limited use and low vaccine efficacy in previously dengue-infected populations over nine years of age, and there is an urgent need to develop second-generation dengue Vaccines (3,4). Contents of the invention [0003] One of the objects of the present...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/40C07K16/10A61K39/12A61K39/42
CPCA61K39/12A61K2039/5258C12N2770/24134C07K16/1081C07K2317/55C07K2317/76A61P31/14Y02A50/30C07K14/005C12N2770/24122C12N2770/24123
Inventor 赵黛瑜
Owner 赵黛瑜
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