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Device, system and method for generating micro-droplets

A technology for generating device and micro-droplets, applied in the field of dispensing and measuring micro-liquids, can solve problems such as small volume error, and achieve the effect of controllable volume error and easy generation of droplets

Active Publication Date: 2022-05-13
BEIJING ZHIYU BIOTECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on this, it is necessary to provide a micro-droplet generating device with a small volume error in view of the current problems, and also provide a generating system and a generating method using the above-mentioned micro-droplet generating device

Method used

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  • Device, system and method for generating micro-droplets
  • Device, system and method for generating micro-droplets
  • Device, system and method for generating micro-droplets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] The microduct 100 is made of a non-rigid polypropylene material with a hardness of Shore D42. The inner diameter of the first opening 110 of the micropipe 100 is 150 microns, the outer diameter is 300 microns, and the length of the vibration radius is 6 cm. The vibration frequency of the rotary vibration mechanism 200 is 100 Hz, and the vibration amplitude voltage is 700 mVpp. The amplitude of the first opening 110 of the microchannel 100 is 0.1 mm.

[0125] The first opening 110 of the micropipe 100 is connected with the fluid drive mechanism 300 through the joint 230 and the capillary 310; Insert below the liquid surface of the second liquid 610 at an included angle of 30 degrees, so that the vertical distance from the center of the nozzle of the first opening 110 of the micropipe 100 to the liquid surface of the second liquid 610 is 1.5mm, and push the fluid drive mechanism 300 The syringe 350 in the cavity pushes the first liquid 130 in its chamber to the nozzle o...

Embodiment 2

[0127] The micropipe 100 is made of stainless steel. The first opening 110 has an inner diameter of 60 microns, an outer diameter of 200 microns, and a vibration radius of 5 cm. The vibration frequency of the rotary vibration mechanism 200 is 100 Hz, and the vibration amplitude voltage is 400 mVpp. The amplitude of the first opening 110 of the microchannel 100 was 1 mm.

[0128] The second opening 120 of the micropipe 100 is connected to the fluid drive mechanism 300 through the joint 230 and the capillary 310; the first opening 110 of the micropipe 100 is inserted into the second liquid at an angle of 90 degrees to the liquid surface of the second liquid 610 610 below the liquid level, so that the vertical distance from the nozzle center position of the first opening 110 of the microchannel 100 to the liquid level of the second liquid 610 is 1.5 mm, and the syringe 350 in the fluid drive mechanism 300 is pushed to move the second liquid 610 to the second liquid in its cavity....

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Abstract

The invention provides a micro-droplet generating device, system and method, which relate to the technical field of measuring and distributing micro-liquids. The micro-droplet generating device of the present invention includes a micro-pipe, the micro-pipe has a first opening for outputting the first liquid, and a rotational vibration mechanism for driving the micro-pipe to rotate and vibrate. The micro-droplet generating device of the invention adopts the rotational vibration to drive the micro-pipe. Under the action of the high-frequency periodic inertial force and centrifugal force generated by the rotational vibration, when the liquid in the micro-pipe is injected into another immiscible liquid The size of the generated emulsified microdroplets is precisely controllable, so that the volume error of large batches of droplets can be controlled.

Description

technical field [0001] The invention relates to the technical field of measuring and distributing micro-liquids, in particular to a micro-droplet generation device, system and method based on micro-channels. Background technique [0002] At present, there is a wide demand for precise operation of trace liquids in medical clinical testing, nanomaterial preparation, food and environmental monitoring, biochemical analysis and other application fields. One of the core technologies of micro-liquid manipulation is to further divide microliter-level liquids into micro-reaction systems with nanoliter or even picoliter volumes. A main technical branch of micro-reaction system generation is the generation of emulsified micro-droplets. [0003] In recent years, a variety of microdroplet generation techniques have been reported in the literature, such as membrane emulsification, spray emulsification, microfluidic chip, micropipe injection / spraying, etc. The recent Chinese invention pa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
CPCB01L3/502707B01L3/50273B01L2300/12B01L2400/0475B01L2400/0433
Inventor 李昂
Owner BEIJING ZHIYU BIOTECH LTD
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