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Method for measuring total titratable amine in sevelamer carbonate through potentiometric titration method

A technique of sevelamer carbonate and potentiometric titration, which is applied in the field of chemical analysis, can solve problems such as large errors and unsharp titration jumps, and achieve the effect of obvious potentiometric titration, sudden jumps in potentiometric titration, and easy control

Inactive Publication Date: 2019-08-06
SHANDONG XINHUA PHARMA
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  • Claims
  • Application Information

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Problems solved by technology

[0002] Sevelamer Carbonate is a high molecular polymer that cannot be absorbed by humans. It carries multiple amino groups. Since the amino groups in the molecule of this product are weak bases, the titration jump at the equivalence point will not be sharp. According to traditional The method of judging the end point of the reaction with an acid-base indicator has a large error

Method used

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  • Method for measuring total titratable amine in sevelamer carbonate through potentiometric titration method
  • Method for measuring total titratable amine in sevelamer carbonate through potentiometric titration method
  • Method for measuring total titratable amine in sevelamer carbonate through potentiometric titration method

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Experimental program
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Effect test

Embodiment 1

[0041] (1) Take about 1.0 g of sevelamer carbonate (hereinafter referred to as this product), accurately weigh it and place it in a titration cup;

[0042] (2) Accurately measure 15ml of 1.0mol / L hydrochloric acid solution with a pipette, add 35ml of water, and stir for 40 minutes;

[0043] (3) According to the potentiometric titration method, carefully set the titration parameters, use a glass electrode, and titrate the above solution with 1.0 mol / L sodium hydroxide titration solution.

[0044] (4) Titration ends, and the content of total titratable amines is obtained by calculation.

Embodiment 2

[0046] (1) Take about 1.0g of this product, accurately weigh it and place it in a titration cup;

[0047] (2) Accurately measure 13ml of 1.0mol / L hydrochloric acid solution with a pipette, add 35ml of water, and stir for 40 minutes;

[0048] (3) According to the potentiometric titration method, carefully set the titration parameters, use a glass electrode, and titrate the above solution with 1.0 mol / L sodium hydroxide titration solution.

[0049] (4) Titration ends, and the content of total titratable amines is obtained by calculation.

Embodiment 3

[0051] (1) Take about 1.0g of this product, accurately weigh it and place it in a titration cup;

[0052] (2) Accurately measure 17ml of 1.0mol / L hydrochloric acid solution with a pipette, add 35ml of water, and stir for 40 minutes;

[0053] (3) According to the potentiometric titration method, carefully set the titration parameters, use a glass electrode, and titrate the above solution with 1.0 mol / L sodium hydroxide titration solution.

[0054] (4) Titration ends, and the content of total titratable amines is obtained by calculation.

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Abstract

The invention discloses a method for measuring total titratable amine in sevelamer carbonate through a potentiometric titration method and belongs to the technical field of chemical analysis. The method includes the following steps that: 1.0g of sevelamer carbonate is taken, is precisely weighed, and is added into a titration cup; 13 to 17ml of a 1.0 mol / L hydrochloric acid solution is added intothe titration cup, and 30 to 40 ml of water is added to the titration cup, an obtained solution is stirred for 30 to 50 minutes; and according to the potentiometric titration method, a glass electrodeis adopted, and the above solution is titrated with a 1.0 mol / L sodium hydroxide titration solution. The jump of the potentiometric titration applied by the method of the invention is obvious; and the precision and accuracy of the potentiometric titration are qualified. Compared with traditional acid-base titration, the potentiometric titration has the advantages of high efficiency, simple operation, easiness in mastering and the like.

Description

technical field [0001] The invention relates to the technical field of chemical analysis, in particular to a method for determining total titratable amines in sevelamer carbonate by potentiometric titration. Background technique [0002] Sevelamer Carbonate is a high molecular polymer that will not be absorbed by humans. It carries multiple amino groups. Since the amino groups in the molecule of this product are weak bases, the titration jump at the equivalence point will not be sharp. According to traditional The method of judging the end point of the reaction with an acid-base indicator has a large error. The potentiometric titrator indicates the end point of the titration by the sudden jump of the electrode potential, which can effectively monitor the end point of the titration. The invention adopts a high-sensitivity full-automatic potentiometric titrator, carefully designs titration parameters, can effectively monitor the equivalence point, and realizes the determinati...

Claims

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Application Information

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IPC IPC(8): G01N31/16
CPCG01N31/164
Inventor 乔苗王谢栋郑忠辉
Owner SHANDONG XINHUA PHARMA
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