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Methods for directed folding assembly or dimerization of proteins by templated assembly reactions

A protein and fusion protein technology, applied in the fields of biochemical equipment and methods, organic chemistry, pharmaceutical formulations, etc., can solve the problems of not delivering cytotoxic or cytostatic intervention, and the elimination of dangerous cells is not particularly effective.

Inactive Publication Date: 2019-08-13
TRIBIOTICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing nucleic acid-targeted therapies, such as siRNA, are able to downregulate the expression of potentially dangerous genes but do not deliver potent cytotoxic or cytostatic interventions and are therefore not particularly effective at eliminating dangerous cells themselves

Method used

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  • Methods for directed folding assembly or dimerization of proteins by templated assembly reactions
  • Methods for directed folding assembly or dimerization of proteins by templated assembly reactions
  • Methods for directed folding assembly or dimerization of proteins by templated assembly reactions

Examples

Experimental program
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Embodiment approach 1

[0347] Embodiment 1. A haploid-ligand complex comprising: a haploid, wherein said haploid comprises a polynucleotide substantially complementary to a target nucleic acid molecule; and 5 of said haploid ' or 3' end-linked ligand, wherein the ligand comprises a ligand-partner binding site.

Embodiment approach 2

[0348] Embodiment 2. The haploid-ligand complex of embodiment 1, wherein the polynucleotide comprises DNA nucleotides, RNA nucleotides, phosphorothioate modified nucleotides, 2-O -Alkylated RNA nucleotides, halogenated nucleotides, locked nucleic acid nucleotides (LNA), peptide nucleic acids (PNA), morpholino nucleic acid analogs (morpholino compounds), pseudouridine nucleotides , xanthine nucleotides, inosine nucleotides, 2-deoxyinosine nucleotides, DNA analogs with L-ribose (L-DNA), Xeno nucleic acid (XNA) analogs, or capable of forming bases Other nucleic acid analogs of the pair, or artificial nucleic acid analogs with altered backbones, or any combination thereof.

Embodiment approach 3

[0349] Embodiment 3. The haploid-ligand complex of embodiment 1 or embodiment 2, wherein the ligand is a small molecule ligand or an interacting protein domain.

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Abstract

The present disclosure provides nucleic acid molecules, compositions, and kits comprising the same, and methods for producing templated assembly products.

Description

technical field [0001] The present disclosure relates in part to nucleic acid molecules, compositions and kits comprising the nucleic acid molecules, and methods for producing templated assembly products. Background technique [0002] The goal of drug development is to deliver effective biotherapeutic interventions to disease-causing cells, such as virus-infected cells, neoplastic cells, cells producing autoimmune responses, and other dysregulated or dysfunctional cells. Examples of effective biotherapeutic interventions capable of combating disease-causing cells include toxins, pro-apoptotic agents, and immunotherapies that redirect immune cells to eliminate disease-causing cells. Unfortunately, the development of these agents is very difficult due to the high risk of toxicity to adjacent normal cells or the overall health of the patient. [0003] An approach that has emerged to allow the delivery of effective interventions to disease-causing cells while attenuating toxici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/115A61K31/713
CPCA61K31/713C12N15/11C12N2310/3513C12N15/111C12N15/1068C07D401/12C07D401/14C12P19/34G01N33/50
Inventor 伊恩·邓恩马修·劳勒
Owner TRIBIOTICA