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A kind of highly absorbable natural astaxanthin eye cream and preparation method thereof

A technology of astaxanthin and eye cream, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of poor stability, limited application, poor solubility of astaxanthin, etc., and achieve excellent stability and wrinkle improvement Effect

Active Publication Date: 2022-05-10
RIZHAO POLYTECHNIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, astaxanthin has defects such as poor solubility, poor stability, and low bioavailability, which severely limit its application.

Method used

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  • A kind of highly absorbable natural astaxanthin eye cream and preparation method thereof
  • A kind of highly absorbable natural astaxanthin eye cream and preparation method thereof
  • A kind of highly absorbable natural astaxanthin eye cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation method of astaxanthin eye cream comprises the following steps:

[0034] 1) Preparation of free astaxanthin:

[0035] Using Haematococcus pluvialis as the biological raw material for preparing esterified astaxanthin, weigh 1kg of Haematococcus pluvialls powder, add 10 times the weight of raw material (W / V) absolute ethanol, and repeatedly extract 2 times, each Sub-leaching for 1h, combining the extracts, and then concentrating the extracts under reduced pressure to remove the solvent to obtain the crude extract; then adding the crude extract to 30 times the mass concentration of the volume is in 2% potassium hydroxide solution, at 4 The saponification reaction was carried out under the condition of ℃ and nitrogen gas. After the reaction, the reaction system was placed at -2 ℃ for 2 hours, and then filtered to collect the crystallized purple-red substance to obtain refined free astaxanthin.

[0036] 2) Heat treatment of free astaxanthin:

[0037] Weigh a...

Embodiment 2

[0043] A preparation method of astaxanthin eye cream, comprising the following steps:

[0044] 1) Preparation of free astaxanthin: use Haematococcus pluvialls as the biological raw material for preparing esterified astaxanthin, weigh 100g of Haematococcus pluvialls powder, add 20 times the raw material quality (W / V) of ethyl acetate to soak After extracting for 4 hours, the extract was collected by filtration, and then the extract was concentrated under reduced pressure, and the solvent was removed to obtain a crude extract. Then, homogeneously emulsify with 1 times the mass of Tween 80, and then add lipase-containing phosphate buffer, the amount of enzyme is 10U / μg total astaxanthin, the enzymatic hydrolysis conditions are 40°C, pH5.5, and the enzymatic hydrolysis time for 12h. After the enzymatic hydrolysis, add ethyl acetate to the system until the emulsion is broken, collect the oil phase, and concentrate under reduced pressure to obtain free astaxanthin;

[0045] 2) Hea...

Embodiment 3

[0051] A preparation method of astaxanthin eye cream, comprising the following steps:

[0052] 1) Preparation of free astaxanthin: Weigh 100 g of Phaffia rhodozyma and put it in an extraction kettle in a 1L supercritical extraction device. The temperature of the extraction kettle is set at 40°C and the pressure is set at 30MPa. 2 The flow rate is set at 20L / h, the temperature and pressure of the separation tank I are 35°C and 10MPa respectively, the temperature of the separation tank II is 40°C, and the CO 2 The flow rate of the fluid is 30L / h, and the continuous dynamic extraction time is 3h. The extract is released from the separation tank irregularly, collected and stored in the container. The extract is a dark red viscous substance, and the free shrimp green is obtained. The crude extract of element; Then obtain refined free state astaxanthin by column chromatography;

[0053] 2) Heat treatment of free astaxanthin: Weigh and dissolve the astaxanthin obtained in step 1) in...

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Abstract

The invention provides an astaxanthin eye cream that can be absorbed efficiently, which is prepared by using heat-treated free astaxanthin as a raw material; wherein the heat-treated free astaxanthin is extracted from The astaxanthin is extracted from the raw material, then treated by enzymatic hydrolysis or saponification, and the processed product is finally prepared by heat treatment in a solvent system. The astaxanthin eye cream of the present invention can effectively scavenge free radicals, thereby delaying eye skin aging, eliminating wrinkles and fine lines; secondly, the astaxanthin in the eye cream can effectively penetrate the blood-retinal barrier, and can effectively prevent retinal damage. Oxidation and damage to photoreceptor cells. Moreover, the product of the present invention has strong storage stability, meets the shelf life requirements of the product, and is crucial to the development of the astaxanthin eye cream product.

Description

technical field [0001] The invention belongs to the technical field of cosmetic preparation, and in particular relates to a highly absorbable natural astaxanthin eye cream and a preparation method thereof. Background technique [0002] Eye cream is mainly used to protect the skin around the eyes. As we all know, the skin around the eyes is the thinnest skin tissue in the human body, with a thickness of only 0.33-0.36 mm. It is very delicate and fragile, and requires extra maintenance. [0003] Astaxanthin, as a fat-soluble carotenoid, has many physiological functions and is called "super antioxidant". Studies have shown that the antioxidant capacity of astaxanthin is 100 times that of vitamin E. Its excellent antioxidant capacity endows it with a powerful effect of scavenging free radicals and delaying aging, so it is widely used in functional cosmetics. And astaxanthin, as the only carotenoid that can penetrate the blood-retinal barrier, is of great significance for relie...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/35A61K8/37A61K8/67A61K8/92A61K8/06A61Q17/04A61Q19/00A61Q19/08
CPCA61K8/35A61K8/37A61K8/678A61K8/922A61K8/068A61Q19/005A61Q19/08A61Q17/04
Inventor 周庆新朱文韬谷彩霞刘舒婷李玉环谭思琪
Owner RIZHAO POLYTECHNIC
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