Nano cuprous oxide/silk fibroin complex and preparation method thereof

A technology of nano-cuprous oxide and silk fibroin, applied in the field of nano-materials, can solve problems such as affecting performance, uneven dispersion of cuprous oxide, easy oxidation of cuprous oxide, etc., achieving low cost, easy industrial production, strong The effect of applying value

Active Publication Date: 2021-07-20
JIAXING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The patent application with the publication number CN106676753B discloses an antibacterial nanofiber (membrane) containing nano-cuprous oxide, silk fibroin and polyethylene oxide and its preparation method. Ethylene blended aqueous solution is electrospun to prepare nanofibers with antibacterial properties. This application directly uses cuprous oxide as raw material, and the direct blending solution will lead to partial agglomeration of cuprous oxide, resulting in cuprous oxide in nanofibers. Uneven dispersion in the medium, and the uneven dispersion of cuprous oxide is easy to oxidize, thus affecting the performance of the final product

Method used

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  • Nano cuprous oxide/silk fibroin complex and preparation method thereof
  • Nano cuprous oxide/silk fibroin complex and preparation method thereof
  • Nano cuprous oxide/silk fibroin complex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] First add 100 grams of cocoons to 1 liter of 0.5w / v% Na 2 CO 3 In the aqueous solution, boil for 30min, repeat the treatment three times, fully wash with distilled water, put it in a drying oven at 45°C after washing, and dry to obtain degummed silk fibers; 2 :C 2 h 5 OH:H 2 The molar ratio of O=1:2:8 is used to prepare a ternary solvent, and the silk fiber is hydrolyzed at a constant temperature in a water bath at 70° C. for 1 hour at a bath ratio of 1:10 to obtain a completely dissolved brownish-yellow silk fiber hydrolysis solution; Put the hydrolyzed solution into a dialysis bag, dialyze with distilled water for 72 hours, put the dialyzed silk fiber hydrolyzed solution into -80°C for 12 hours, and then freeze-dry it at -58°C until dry to obtain white, loose porous, spongy Silk fibroin: Compared with the existing commercially available silk fibroin, the silk fibroin prepared by the above steps of the present invention has the advantages of uniform molecular weigh...

Embodiment 2

[0038] Add 0.2g silk fibroin to 10mL water and stir until completely dissolved to obtain a silk fibroin solution; add 0.08mol.L -1 Add 10mL of copper sulfate solution to the silk fibroin solution and stir evenly, add 0.2mol.L -1 Sodium hydroxide to adjust the pH value to 12, add 0.08mol.L -1 Take 20 mL of vitamin C solution, react at room temperature (25° C.) for 48 hours, dialyze for 3 days, and freeze-dry to obtain nano-cuprous oxide / silk fibroin complex.

Embodiment 3

[0040] Add 0.2g silk fibroin to 10mL water and stir until completely dissolved to obtain a silk fibroin solution. Add 0.04mol.L -1 Add 10mL of copper sulfate solution to the silk fibroin solution and stir evenly, add 0.2mol.L -1 Sodium hydroxide to adjust the pH value to 12, add 0.08mol.L -1 Vitamin C solution, 20mL, reacted at room temperature (25°C) for 48 hours, dialyzed for 3 days, and freeze-dried to obtain nano-cuprous oxide / silk fibroin complex.

[0041] Table 1 below shows the contents of nitrogen, oxygen, carbon and copper elements in the nano-cuprous oxide / silk fibroin composite prepared in different examples from X-ray photoelectron spectroscopy (XPS).

[0042] Table 1 Contents of nitrogen, oxygen, carbon and copper elements in the nano-cuprous oxide / silk fibroin composites prepared in different examples.

[0043] Table 1

[0044]

[0045] The data in the above table shows that with the increase of the concentration of copper sulfate, the content of copper ele...

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Abstract

The invention discloses a nano-cuprous oxide / silk fibroin complex and a preparation method thereof, which is characterized in that the main raw materials for preparing the complex include: 1.0-2.0 parts of silk fibroin, copper sulfate pentahydrate 0.5-2 parts, sodium hydroxide 0.58-1.92, vitamin C 0.7-2.8 parts. The preparation steps include: dissolving silk fibroin in deionized water to prepare a silk fibroin solution; preparing copper sulfate pentahydrate into a copper sulfate solution, adding it to the silk fibroin solution and stirring evenly, and then adding sodium hydroxide solution to adjust the pH value 10-12; vitamin C is formulated into a solution and added to the solution obtained in the above step (2), reacted at room temperature for 30-60 hours, dialyzed for 2-4 days, and freeze-dried to obtain nano-cuprous oxide / silk fibroin porous sponge. It can effectively hinder the agglomeration of nano-cuprous oxide particles, increase the stability of nano-cuprous oxide, prevent its oxidation, and prepare materials with various shapes.

Description

technical field [0001] The invention belongs to the field of nanometer materials, and in particular relates to a nanometer cuprous oxide / silk fibroin compound and a preparation method thereof. Background technique [0002] Silk fibroin is degummed from silkworm cocoons. It is a very abundant natural protein in nature. Silk fibroin extracted from silk has a unique molecular structure, excellent mechanical properties, good moisture absorption and moisturizing properties, and good biological phase. Capacitance, biodegradability, non-immunogenicity and other excellent properties. It can be prepared into nanoparticles, membranes, fibers, porous sponges, 3D printing scaffolds, etc. Has been widely used in food, cosmetics, biomedical and other fields. [0003] As a monovalent oxide of copper, nano-cuprous oxide is a new type of p-type semiconductor material that can be excited by visible light and has a band gap of 2.2 eV. Due to its special crystal structure, it has been applied...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L89/00C08K3/22C08J9/28
CPCC08J9/28C08J2389/00C08K3/22C08K2003/2248C08K2201/011C08L89/00
Inventor 张葵花颜志勇连媛李喆姚勇波生俊露
Owner JIAXING UNIV
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