Use of Funaosu for preparing medicine for treating decompression sickness

A technology of decompression sickness and drugs, applied in the field of medicine, can solve problems such as no reports, achieve the effects of reducing morbidity and mortality, improving animal survival rate, and improving model animal behavior scores

Pending Publication Date: 2019-09-06
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But kaempferol-3-O-rutinoside has no report on

Method used

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  • Use of Funaosu for preparing medicine for treating decompression sickness
  • Use of Funaosu for preparing medicine for treating decompression sickness
  • Use of Funaosu for preparing medicine for treating decompression sickness

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0022] Example: Prevention and treatment of Funaosu on decompression sickness in rats

[0023] 1. Test materials

[0024] 1.1. Experimental instrument

[0025] The DWC150 animal experiment pressurized chamber was purchased from Shanghai 701 Yangyuan Medical Oxygen Chamber Factory.

[0026] 1.2. Samples for testing:

[0027] Fu Nao Su injection was prepared by the research team according to the preparation process. Preparation specifications: 10mg / ml.

[0028] 2. Experimental animals

[0029] Strain: SD rat

[0030] Sex: male

[0031] Weight: 240~280 grams

[0032] Source: Shanghai Slack Company

[0033] Feeding: constant temperature purification and ventilation animal room, free eating and drinking, 25±2℃.

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PUM

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Abstract

The invention relates to the technical field of medicine, in particular to a new use of kaempferol-3-O-rutinoside in - preparation of a medicine for preventing and treating decompression sickness. Theresearch shows that the kaempferol-3-O-rutinoside can reduce the incidence and mortality of decompression sickness in rats, and is non-toxic and safe to use, so kaempferol-3-O-rutinoside can be usedfor preparation of drugs for control of decompression sickness.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of kaempferol-3-O-rutinoside in the preparation of medicines for preventing and treating decompression sickness. Background technique [0002] Decompression sickness is a unique disease in diving, high pressure and aerospace operations. It often occurs in divers, astronauts or pilots during rapid decompression and after decompression, which seriously threatens the safety of diving and flying personnel. Decompression sickness is caused by rapid decompression of inert gas after supersaturation to generate bubbles, which in turn leads to pathological reactions such as vascular embolism and tissue mechanical compression. In addition, bubbles also cause a series of biochemical and inflammatory reactions, such as platelet aggregation, inflammatory cell activation, cytokine release, vascular endothelial injury, etc., which induce intravascular coagulation and inflammato...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P29/00A61P7/02A61P43/00
CPCA61K31/7048A61P7/02A61P29/00A61P43/00
Inventor 郭美丽
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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