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Drug delivery system targeting tumor cells, preparation method and application thereof

A tumor cell and drug delivery technology, applied in the field of biomedicine, can solve problems such as damage, easy generation of drug resistance, toxic and side effects, etc.

Active Publication Date: 2021-10-22
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, doxorubicin is more likely to produce drug resistance during clinical application, which seriously affects the clinical therapeutic effect of doxorubicin.
At the same time, doxorubicin will also produce serious toxic side effects in application, and dose-dependent irreversible cardiotoxicity, liver damage, brain and kidney damage may occur after long-term use

Method used

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  • Drug delivery system targeting tumor cells, preparation method and application thereof
  • Drug delivery system targeting tumor cells, preparation method and application thereof
  • Drug delivery system targeting tumor cells, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 Preparation of drug delivery system AuNR-LAX targeting tumor cells

[0054] In this example, the preparation of the drug delivery system AuNR-LAX targeting tumor cells includes the following steps:

[0055] 1. Preparation of LAX dimethylformamide solution

[0056] Wherein, the LAX is lipoic acid-glycine-phenylalanine-leucine-glycine-doxorubicin.

[0057] Synthesize glycine-phenylalanine-leucine-glycine according to the conventional method of polypeptide synthesis, and then carry out amidation reaction, so that glycine-phenylalanine-leucine-glycine can be combined with Adriamycin through the carboxyl group on the glycine at the C-terminal of the polypeptide Glycine-phenylalanine-leucine-glycine is connected with lipoic acid through the amino group on the N-terminal glycine of the polypeptide to obtain LAX; 0.34mg LAX is dissolved in 3.4mL dimethylformamide to prepare 0.09 mM solution of LAX in dimethylformamide.

[0058] 2. Preparation of gold nanorods (AuNR...

Embodiment 2

[0069] Example 2 Determination of AuNR-LAX drug resistance index of drug delivery system targeting tumor cells and its influence on normal cell viability

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Abstract

The invention provides a drug delivery system targeting tumor cells, a preparation method and application thereof. The drug delivery system is a gold nanorod modified by lipoic acid-glycine-phenylalanine-leucine-glycine-doxorubicin (abbreviated as LAX). First, gold nanorods with photothermal conversion properties were synthesized, and LAX molecules were modified on the surface to obtain AuNR‑LAX nano drug delivery system. By evaluating the anti-tumor activity of breast cancer cells MCF‑7 and MCF‑7 / ADR drug-resistant cells, it was shown that AuNR‑LAX has anti-tumor activity, and with prolonged administration, the anti-tumor effect on sensitive cells and drug-resistant cells The activities are all enhanced, and it has the ability to overcome the multidrug resistance of tumor cells. AuNR‑LAX reduces its damaging effect on normal cells compared to doxorubicin.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a drug delivery system targeting tumor cells and its preparation method and application. Background technique [0002] Due to the occurrence of tumors, the health and safety of human beings are greatly threatened, and the research on tumor treatment has been widely concerned. Traditional tumor treatment methods include surgery, radiotherapy, and chemotherapy. Among them, chemical drug therapy is chemotherapy, and the use of chemical drugs to treat tumors is one of the important methods commonly used in clinical practice. During the course of chemotherapy, tumor cells often develop drug resistance to chemotherapy drugs, which seriously affects the therapeutic efficiency of clinical chemotherapy and leads to the failure of clinical tumor chemotherapy. It has been found that the failure of most chemotherapy patients or postoperative recurrence is caused by drug resistance. In addition,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/54A61K47/55A61K47/64A61K47/65A61P35/00A61K31/704
CPCA61K31/704A61K41/0052A61K47/545A61K47/55A61K47/64A61K47/65A61P35/00A61K2300/00
Inventor 房晨婕支晓敏钱迪
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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