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Drug administration system targeting tumor cells and preparation method and application of drug administration system

A tumor cell and drug delivery technology, applied in the field of biomedicine, can solve the problems of easy generation of drug resistance, dose dependence, affecting the clinical treatment effect of doxorubicin, etc.

Active Publication Date: 2019-09-17
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Claims
  • Application Information

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Problems solved by technology

Therefore, doxorubicin is more likely to produce drug resistance during clinical application, which seriously affects the clinical therapeutic effect of doxorubicin.
At the same time, doxorubicin will also produce serious toxic side effects in application, and dose-dependent irreversible cardiotoxicity, liver damage, brain and kidney damage may occur after long-term use

Method used

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  • Drug administration system targeting tumor cells and preparation method and application of drug administration system
  • Drug administration system targeting tumor cells and preparation method and application of drug administration system
  • Drug administration system targeting tumor cells and preparation method and application of drug administration system

Examples

Experimental program
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Effect test

Embodiment 1

[0053] Example 1 Preparation of drug delivery system AuNR-LAX targeting tumor cells

[0054] In this example, the preparation of the drug delivery system AuNR-LAX targeting tumor cells includes the following steps:

[0055] 1. Preparation of LAX dimethylformamide solution

[0056] Wherein, the LAX is lipoic acid-glycine-phenylalanine-leucine-glycine-doxorubicin.

[0057] Synthesize glycine-phenylalanine-leucine-glycine according to the conventional method of polypeptide synthesis, and then carry out amidation reaction, so that glycine-phenylalanine-leucine-glycine can be combined with Adriamycin through the carboxyl group on the glycine at the C-terminal of the polypeptide Glycine-phenylalanine-leucine-glycine is connected with lipoic acid through the amino group on the N-terminal glycine of the polypeptide to obtain LAX; 0.34mg LAX is dissolved in 3.4mL dimethylformamide to prepare 0.09 mM solution of LAX in dimethylformamide.

[0058] 2. Preparation of gold nanorods (AuNR...

Embodiment 2

[0069] Example 2 Determination of AuNR-LAX drug resistance index of drug delivery system targeting tumor cells and its influence on normal cell viability

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Abstract

The invention provides a drug administration system targeting tumor cells and a preparation method and application of the drug administration system. The drug administration system is a gold nanorod modified by lipoic acid-glycine-phenylalanine-leucine-glycine-doxorubicin (LAX for short). Firstly, a gold nanorod with photothermal conversion properties is synthesized, and the surface of the gold nanorod is modified by LAX molecules to obtain the AuNR-LAX nano drug delivery system. By evaluating the anti-tumor activity of breast cancer cells MCF-7 and MCF-7 / ADR drug-resistant cells, it is indicated that the AuNR-LAX has anti-tumor activity, as the drug administration time goes on, the anti-tumor activity of the AuNR-LAX to sensitive cells and drug-resistant cells is improved, and the AuNR-LAX has the capability of overcoming multidrug resistance of the tumor cells. Compared with doxorubicin, the AuNR-LAX has the advantage that the damage of the AuNR-LAX to normal cells can be reduced.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a drug delivery system targeting tumor cells and its preparation method and application. Background technique [0002] Due to the occurrence of tumors, the health and safety of human beings are greatly threatened, and the research on tumor treatment has been widely concerned. Traditional tumor treatment methods include surgery, radiotherapy, and chemotherapy. Among them, chemical drug therapy is chemotherapy, and the use of chemical drugs to treat tumors is one of the important methods commonly used in clinical practice. During the course of chemotherapy, tumor cells often develop drug resistance to chemotherapy drugs, which seriously affects the therapeutic efficiency of clinical chemotherapy and leads to the failure of clinical tumor chemotherapy. It has been found that the failure of most chemotherapy patients or postoperative recurrence is caused by drug resistance. In addition,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/54A61K47/55A61K47/64A61K47/65A61P35/00A61K31/704
CPCA61K31/704A61K41/0052A61K47/545A61K47/55A61K47/64A61K47/65A61P35/00A61K2300/00
Inventor 房晨婕支晓敏钱迪
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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