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Composite nanomaterial with core-shell structure and its preparation method and application

A technology of composite nanomaterials and core-shell structure, which can be applied in preparations for in vivo tests, medical preparations containing active ingredients, wave energy or particle radiation treatment materials, etc., can solve the problem that SERS reagents cannot be used for imaging diagnosis, SERS activity, etc. problems such as lowering and instability

Active Publication Date: 2017-12-29
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biological toxicity of silver nanomaterials is high, and its SERS activity is greatly reduced due to its easy oxidation.
Due to its potential toxicity and instability, SERS reagents prepared from a single silver nanoparticle are not suitable for imaging diagnosis in vivo

Method used

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  • Composite nanomaterial with core-shell structure and its preparation method and application
  • Composite nanomaterial with core-shell structure and its preparation method and application
  • Composite nanomaterial with core-shell structure and its preparation method and application

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preparation example Construction

[0098] The present invention also provides a kind of preparation method of described composite nanomaterial, described method comprises the steps:

[0099] a) providing a first solution, a second solution, a third solution and a fourth solution, wherein,

[0100] The first solution comprises a first solvent and silver nanoparticles dissolved in the first solvent;

[0101] The second solution comprises a second solvent and a first Raman detection molecule dissolved in the second solvent;

[0102] The third solution comprises a third solvent and gold or platinum nanoparticles dissolved in the third solvent;

[0103] The fourth solution comprises a fourth solvent and a second Raman detection molecule dissolved in the fourth solvent;

[0104] b) under stirring conditions, mix the first solution and the second solution to obtain a first mixed solution containing silver nanoparticles modified by the first Raman detection molecule;

[0105] c) under stirring conditions, mix the th...

Embodiment 1

[0169] Example 1 Preparation of Silver@Gold Nanostar Structure and SERS Imaging and Photothermal Therapy

[0170] making process:

[0171] 1. Prepare Ag nanoparticles with a particle size of 40 nm according to existing literature methods.

[0172] 2. Add 1 mL of an ethanol solution of aminothiophenol with a concentration of 0.5 mM to 10 mL of an aqueous solution of Ag nanoparticles with a concentration of 1 mM, stir for 60 min, collect it by centrifugation and wash it several times with deionized water, and redisperse it in 10 mL deionized water.

[0173] 3. To 10 mL of 1 mM HAuCl 4 10 microliters of 0.1M hydrochloric acid solution was added to the aqueous solution, and 1 mL of the above-mentioned Ag nanoparticle solution of modified aminothiophenol was added. After stirring for 2 minutes, 10 mM AgNO was added to it at the same time. 3 50 microliters of aqueous solution of 50 mM ascorbic acid and 10 microliters of aqueous solution of 50 mM ascorbic acid. After reacting for ...

Embodiment 2

[0184] Example 2 Preparation of silver@gold nanoparticle structure and SERS imaging and photothermal therapy

[0185] making process:

[0186] 1. Prepare Ag nanoparticles with a particle size of 20 nm according to existing literature methods.

[0187] 2. Add 1 mL of DTTC dimethyl sulfoxide solution with a concentration of 0.3 mM to 10 mL of an aqueous solution of Ag nanoparticles with a concentration of 0.1 mM, stir for 10 min, collect it by centrifugation and wash it with deionized water for several times, and then redisperse in 10 mL of deionized water.

[0188] 3. Add 1 mL of an aqueous solution of 5nm gold nanoparticles at a concentration of 0.1 mM to 10 mL of the above-mentioned Ag nanoparticles solution for primary modification of DTTC, and stir for 20 minutes to obtain the structure of Ag@Au nanoparticles for primary modification of DTTC. The resultant was collected by centrifugation, washed several times with deionized water, and redispersed in 10 mL of deionized wat...

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Abstract

The invention relates to a composite nanometer material with a core-shell structure, a preparation method and an application thereof. Specifically, the present invention discloses a composite nanomaterial, the composite nanomaterial has a core-shell structure, and includes: silver nanoparticles as the inner core, the surface of the silver nanoparticles carries the first Raman detection molecule; and an outer shell A gold and / or platinum layer, the gold and / or platinum layer is coated on the surface of the silver nanoparticles, and the outer surface of the gold and / or platinum layer away from the silver nanoparticles carries a second Raman Detect molecules. The invention also discloses the preparation method and application of the composite nanometer material. When the composite nanomaterial is applied in the diagnosis and treatment of tumors, a new type of multifunctional molecular probe with low toxicity, high stability, high SERS activity and photothermal therapeutic effect can be obtained.

Description

technical field [0001] The invention relates to the field of materials, in particular to a composite nanomaterial with a core-shell structure and its preparation method and application. Background technique [0002] Multifunctional molecular probes based on nanomaterials have important applications in the diagnosis and treatment of major diseases such as malignant tumors. In particular, noble metal nanomaterials, such as gold, silver, and platinum, have become important SERS active substrate materials due to their advantages of simple preparation and good water solubility. It is well known that silver has the highest SERS activity among noble metal nanomaterials, and the SERS enhancement factor of silver is more than 3 orders of magnitude higher than that of gold or platinum under the same conditions. However, silver nanomaterials have high biological toxicity and are easily oxidized, which greatly reduces their SERS activity. Due to its potential toxicity and instability,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K41/00
Inventor 曾乐勇吴爱国
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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