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A kind of non-enzyme cortisol nanoporous platinum sensing electrode and its preparation method and application

A nanoporous and sensing electrode technology, which is applied in the detection field of chemical or biological substances, can solve the problem that it is difficult to determine the specific concentration of cortisol in the human body, the preparation method of nanoporous platinum is not mature, and platinum alloy platinum and rhodium are difficult to remove, etc. problems, to achieve the effects of regular and clear ligaments, fast preparation speed and good stability

Active Publication Date: 2021-11-16
HUIZHOU LEADAO ELECTRONICS MATERIAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, new alloy systems for preparing nanoporous metals by dealloying have been gradually developed, such as Ni-Cu, Mn-Cu, Si-Pt, Al-Au, Pd-Ni-P, etc. Dealloying treatment can prepare nanoporous metals such as nanoporous palladium (Nanoporous Pd, NPPd), nanoporous gold (Nanoporous Au, NPG), nanoporous silver (Nanoporous Ag, NPS), although the relevant research on existing alloys Mainly platinum and rhodium and other relatively stable alloys, but platinum and rhodium in platinum alloys are difficult to remove, so it is difficult to prepare nanoporous platinum as a precursor, so that the preparation method of nanoporous platinum has no relevant mature technology, and At present, in the process of detecting the concentration of cortisol, when the concentration of cortisol in human plasma is low, it is difficult to measure the specific concentration of human cortisol with general catalytic materials

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  • A kind of non-enzyme cortisol nanoporous platinum sensing electrode and its preparation method and application
  • A kind of non-enzyme cortisol nanoporous platinum sensing electrode and its preparation method and application
  • A kind of non-enzyme cortisol nanoporous platinum sensing electrode and its preparation method and application

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preparation example Construction

[0038] A method for preparing an enzyme-free cortisol nanoporous platinum sensing electrode, comprising the steps of:

[0039] The step of making platinum-tin alloy: electroplating on a conductive substrate to obtain platinum-tin alloy,

[0040] De-tin treatment step: the tin element in the platinum-tin alloy is removed by soaking in hot sulfuric acid to obtain a porous platinum material with a nanostructure on the surface of the platinum alloy.

[0041] The manufacturing step of the sensing electrode: the sensing electrode is manufactured using a nanoporous platinum material.

[0042] In a preferred embodiment, the electroplating method in the step of making platinum-tin alloy includes the following sub-steps:

[0043] Step (1): Dissolve platinum sulfate, potassium pyrophosphate and dipotassium hydrogen phosphate in deionized water respectively to obtain a pre-plating solution;

[0044] Step (2): dissolving stannous pyrophosphate and phosphoric acid in the pre-plating solut...

Embodiment 1

[0057] The steps for preparing the enzyme-free cortisol nanoporous platinum sensing electrode on the interdigital substrate are as follows:

[0058] (1) Preparation of pre-plating solution: Weigh 28.0g of potassium pyrophosphate, 1.9g of platinum sulfate and 8.0g of dipotassium hydrogen phosphate, add to 70ml of deionized water, and dissolve the solution by ultrasonic, add 2ml of phosphoric acid to dilute liquid, cooled to room temperature;

[0059] (2) Preparation of platinum-tin plating solution: Take 1.56 g of stannous pyrophosphate and add it to the pre-plating solution, and adjust the pH value to 8.8;

[0060] (3) Preparation of platinum-tin alloy: select the interdigital electrode as the electroplating substrate, place the interdigital electrode in acetone for 30 minutes, wash it with water for 3 times, and then immerse it in the platinum-tin plating solution with a current density of 1.0ASD and a stirring speed of 300rpm , ready to use after electroplating for 300 s; ...

Embodiment 2

[0069] The steps for preparing the enzyme-free cortisol nanoporous platinum sensing electrode on the carbon paper substrate are as follows:

[0070] (1) Preparation of pre-plating solution: Weigh 28.0g of potassium pyrophosphate, 1.9g of platinum sulfate and 8.0g of dipotassium hydrogen phosphate, add to 70ml of deionized water, and dissolve the solution by ultrasonic, add 2ml of phosphoric acid to dilute liquid, cooled to room temperature;

[0071] (2) Preparation of platinum-tin plating solution: Take 1.56 g of stannous pyrophosphate and add it to the pre-plating solution, and adjust the pH value to 8.8;

[0072] (3) Preparation of platinum-tin alloy: choose carbon paper as the electroplating substrate, put the carbon paper in nitric acid at 90°C for 3 hours, wash it with water for 3 times, soak the substrate in acetone for 10-30s, and then immerse the substrate in a current density of 1.0ASD , electroplating for 300 s in a platinum-tin plating solution with a stirring spee...

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Abstract

The invention discloses an enzyme-free cortisol nano-porous platinum sensing electrode and its preparation method and application, specifically comprising the following steps: electroplating on a conductive substrate to obtain a platinum-tin alloy, soaking the platinum-tin alloy in hot sulfuric acid The tin element is removed, and the porous platinum material with nanostructure is obtained on the surface of the platinum alloy, and the nanoporous platinum material is used to make the sensing electrode. During the preparation process of the enzyme-free cortisol nanoporous platinum sensing electrode, the raw material is clean and easy to obtain. The steps are simple and convenient, the prepared enzyme-free cortisol nanoporous platinum sensing electrode has a three-dimensional nanostructure, and the ligaments are regular and clear. Excellent binding force, fast preparation speed, low energy consumption, good stability, and mature preparation technology.

Description

technical field [0001] The invention relates to the field of detection of chemical or biological substances, in particular to an enzyme-free cortisol nanoporous platinum sensing electrode and its preparation method and application. Background technique [0002] Cortisol (C 24 h 30 o 5 ) is an adrenal cortex hormone extracted from the adrenal cortex that has the strongest effect on carbohydrate metabolism, and it is a kind of glucocorticoid. Cortisol is particularly important in manipulating the links between mood and health, immune cells and inflammation, blood vessels and blood pressure, and maintenance of connective tissues such as bone, muscle and skin. Normally, the body does a good job of controlling cortisol production and regulating the amount of cortisol in the blood, but not always (the latter is more the case). Normal cortisol metabolism follows this circadian rhythm, which is a 24-hour cycle. Generally, cortisol levels vary with time (the concentration range o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/327
CPCG01N27/327
Inventor 奚亚男胡淑锦
Owner HUIZHOU LEADAO ELECTRONICS MATERIAL