A kind of light-colored melanin sunscreen and preparation method thereof

A technology of sunscreen and melanin, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of visible light absorption and unfavorable pursuit of beauty, and achieve good free radical scavenging ability, good biological stability, and good skin retention effect of ability

Active Publication Date: 2021-08-27
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the fact that modern aesthetics requires sun protection and has higher requirements for beauty, high visible light absorption is not conducive to people's pursuit of beauty

Method used

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  • A kind of light-colored melanin sunscreen and preparation method thereof
  • A kind of light-colored melanin sunscreen and preparation method thereof
  • A kind of light-colored melanin sunscreen and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 is the preparation method of polydopamine oligomer.

[0042] Example 1

[0043] A preparation method of polydopamine oligomer, comprising the following steps:

[0044] Step 1, dopamine oxidative self-polymerization,

[0045] Adjust the pH of 5 mg / ml dopamine hydrochloride with ammonia water or sodium hydroxide to ≥10, and react for 1 to 6 hours;

[0046] Step 2, dialysis to obtain oligomers,

[0047] The product obtained in step 1 was dialyzed in ethanol for 1 to 2 days in an 8000Mw dialysis bag, concentrated by rotary evaporation, and then dialyzed in water for 3 days using a 2000Mw dialysis bag to collect polydopamine oligomers with a molecular weight of 2k-8k.

Embodiment 2

[0050] Concentrate the polydopamine oligomer in Step 2 of Example 1 to 50 mg / ml, mix it with 50 mg / ml four-arm boric acid PEG, stir for 30 minutes and then let it stand for 5s-300s to obtain a light-colored melanin sunscreen.

Embodiment 3

[0052] Concentrate the polydopamine oligomer in step 2 of Example 1 to 10 mg / ml, mix it with 10 mg / ml four-arm boric acid PEG, stir for 30 minutes and then let it stand for 5s-300s to obtain a light-colored melanin sunscreen.

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Abstract

Provided are a light-colored melanin sunscreen and a preparation method thereof. Sunscreen is a cross-linked product of polydopamine oligomers and hydrophilic polymers with sulfhydryl groups, amino groups or boronic acids; the molecular weight of polydopamine oligomers is 2k‑8k, and hydrophilic polymers with sulfhydryl groups, amino groups or boronic acids It is multi-arm boronic acid PEG or multi-arm thiol PEG. The gelling pH of the sunscreen is 7‑9, the gelling temperature is room temperature, and the gelling time is 5s‑300s. The preparation method comprises the following steps, step 1, oxidative self-polymerization of dopamine hydrochloride in alkali and air; step 2, separating the middle oligomer by dialysis; step 3, combining the oligomer obtained in step 2 with Hydrophilic polymers with mercapto groups, amino groups or boric acids are mixed and cross-linked to obtain sunscreens. The light-colored melanin sunscreen of the present invention has UV absorption but low visible light absorption; has good skin retention and can be mechanically wiped off by towel; has good biological stability and no skin penetration; has good Ability to scavenge free radicals.

Description

technical field [0001] The invention relates to a light-colored melanin sunscreen and a preparation method thereof, in particular to a light-colored melanin sunscreen with ultraviolet absorption and low visible light absorption and a preparation method thereof, belonging to the field of cosmetics. Background technique [0002] The increase in outdoor work and outdoor sports has led to longer exposure to ultraviolet rays, and prolonged ultraviolet (UV) exposure can have many potential adverse effects on human skin. UV photons can be absorbed by a range of biomolecules, including nucleic acids, proteins, and many low-molecular-weight metabolites, causing them to transform into excited states capable of inducing photochemical reactions that lead to cellular photodamage, resulting in sunburn, skin aging, and skin cancer. According to the mechanism of interaction with biological matter, and according to its overall severity, the solar ultraviolet spectrum can be divided into ultr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/84A61K8/86A61Q17/04
CPCA61K8/84A61K8/86A61Q17/04
Inventor 李乙文胡俊飞郭万才傅裕张小康
Owner SICHUAN UNIV
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