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Mathematical analysis method for in-vitro drug release behaviors of traditional Chinese medicine blood-replenishing film sustained-release tablet

A technology for mathematical analysis and sustained-release tablets, applied in complex mathematical operations, drug reference, etc., can solve the problems of unquantifiable drug release process and less drugs

Active Publication Date: 2019-09-27
惠州卫生职业技术学院
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Problems solved by technology

Master the methods and approaches to control the drug release mechanism, so that a reasonable drug release system can be designed according to the basic characteristics of the drug release process and the requirements of the drug delivery system; Analytical methods of release mechanism, unable to quantify drug release process

Method used

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  • Mathematical analysis method for in-vitro drug release behaviors of traditional Chinese medicine blood-replenishing film sustained-release tablet
  • Mathematical analysis method for in-vitro drug release behaviors of traditional Chinese medicine blood-replenishing film sustained-release tablet
  • Mathematical analysis method for in-vitro drug release behaviors of traditional Chinese medicine blood-replenishing film sustained-release tablet

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Embodiment Construction

[0125] The present invention will be further described below in conjunction with the accompanying drawings.

[0126] A mathematical analysis method for the in vitro drug release behavior of the traditional Chinese medicine blood-enriching film sustained-release tablet. The traditional Chinese medicine blood-enriching film sustained-release tablet is a coated tablet, and the coated tablet includes a tablet core and a film coated outside the tablet core, including the following steps:

[0127] Step 1: When the traditional Chinese medicine blood-enriching film sustained-release tablet reaches a steady state in the dissolution medium, the drug release rate equation in it is:

[0128]

[0129] In formula (1), is the drug release rate, p is the partition coefficient of the drug between the tablet core and the film; Δc is the concentration difference inside and outside the film; when the drug concentration in the dissolution medium is much smaller than the concentration in the ta...

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Abstract

The invention discloses a mathematical analysis method for in-vitro drug release behaviors of a traditional Chinese medicine blood-replenishing film sustained-release tablet, which is characterized in that: assuming that the coating tablet is an isometric coating ball according to the shape of the film coating tablet and the shape change characteristics in the release process, the drug release behaviors are analyzed by adopting a spherical model. In the whole release process, the diffusion coefficient of the medicine in the tablet core is far larger than that of the medicine in the coating film, it is proved that release is a non-dissolution control type release system but a film diffusion control type release system, diffusion of the dissolved medicine is remarkably retarded through the coating film, and the controlled release capacity of the medicine in the traditional Chinese medicine blood-replenishing sustained-release tablet is high. Therefore, the mathematical analysis method for the in-vitro drug release behavior of the traditional Chinese medicine blood-replenishing film sustained-release tablet can accurately quantify the drug release process, and can be used for guiding the design and development of pharmaceutical preparations.

Description

technical field [0001] The invention relates to a mathematical analysis method for the in vitro drug release behavior of traditional Chinese medicine blood-enriching film sustained-release tablets, which belongs to the technical field of drug analysis. Background technique [0002] The research on the drug release mechanism plays an important role in the development of preparations. The research on the drug release mechanism can better understand the various related release factors in essence, and provide a basic basis for the design of the controlled release system. Master the methods and approaches to control the drug release mechanism, so that a reasonable drug release system can be designed according to the basic characteristics of the drug release process and the requirements of the drug delivery system; Analytical methods for the release mechanism cannot quantify the drug release process. Contents of the invention [0003] The technical problem to be solved by the p...

Claims

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Application Information

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IPC IPC(8): G16H70/40G06F17/11
CPCG06F17/11G16H70/40
Inventor 梁可谭载友王璐张浩
Owner 惠州卫生职业技术学院
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