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Method and application for detecting occurrence and severity of cancer based on content of skin keratin fragments and keratin

A technology of keratin fragments and severity, applied in the field of detecting the occurrence and severity of cancer based on skin keratin fragments and keratin content, and can solve problems such as methods without cancer prognosis

Inactive Publication Date: 2019-10-11
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, there is no non-invasive, fast, economical, and home-usable method for judging the prognosis of cancer. Therefore, a non-invasive, fast, economical, and home-usable method for judging whether cancer is present can be used to screen out cancer during physical examination. A non-invasive, fast, and economical method for cancer patients, and a non-invasive, fast, economical, and family-usable method for judging the prognosis of cancer has extremely important socioeconomic significance and clinical value

Method used

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  • Method and application for detecting occurrence and severity of cancer based on content of skin keratin fragments and keratin
  • Method and application for detecting occurrence and severity of cancer based on content of skin keratin fragments and keratin
  • Method and application for detecting occurrence and severity of cancer based on content of skin keratin fragments and keratin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Determination of skin fluorescence mainly from keratin fragments.

[0027] Skin autofluorescent substances mainly include keratin, NAD, FAD, collagen, melanin, etc. Each phosphor has its own characteristic spectrum. We detected the spectrum of autofluorescence of human skin. The peak was found to be between 470 nm‐500 nm, based on this, we believed that the autofluorescence of the skin came from keratin fragments.

Embodiment 2

[0028] Example 2: Confirmation of autofluorescent substances

[0029] In vivo experiment

[0030] The subject's surface keratin was imaged using a microscope. The excitation light used is blue light, and the specific wavelength range is between 470-500nm. The images of the distribution and content of keratin fragments on the body surface of the subjects were collected.

Embodiment 3

[0031] Example 3: Determination of cancer by keratin content in various parts of the body surface

[0032] According to the present invention, the body surface keratin of non-disease population and cancer population is imaged, and it is found that the body surface keratin fragment content of cancer population changes significantly ( figure 1 ). And this change was positively correlated with the severity of cancer.

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Abstract

The invention provides an application for detecting the occurrence and severity of a cancer based on the content of skin keratin fragments and keratin, which is an application of a biomarker in preparing a product for diagnosing cancer; the biomarker is a keratin fragment and keratin. By detecting the content of the keratin fragments, the total keratin content, and related fluorescence or Raman spectroscopy and other properties in the skin of a subject, the occurrence, severity, or prognosis badness degree of the cancers is determined; wherein the keratin content is the sum of all keratin family proteins. Compared with non-cancer populations, the keratin fragments in the skin of a cancer patient is increased, the total keratin content is decreased, and auto-fluorescence images of the keratin fragments in the skin is changed.

Description

technical field [0001] The invention relates to a method for judging the occurrence and severity of cancer based on human skin keratin fragments, keratin content and left-right spatial distribution and its application. Specifically, it refers to judging whether the subject suffers from these cancers and the severity of these cancers by comparing the keratin fragments of human skin, the content of keratin, and the symmetry of their spatial distribution. Background technique [0002] For cancer, so far there is no non-invasive, fast, economical method that can be used at home to determine whether the disease occurs, nor can it be used to screen out cancer patients during physical examination. At the same time, there is no non-invasive, fast, economical, and home-usable method for judging the prognosis of cancer. Therefore, a non-invasive, fast, economical, and home-usable method for judging whether cancer is present can be used to screen out cancer during physical examination....

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N33/68G01N21/64G01N21/65
CPCG01N33/57484G01N33/6881G01N21/6486G01N21/65G01N33/57423G01N33/57438G01N33/57446
Inventor 殷卫海张铭超陶钺李雨嘉
Owner SHANGHAI JIAO TONG UNIV
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