Immune checkpoint inhibitor treatment-related biomarker interpretation system and its construction method and device

Abstract

A guidance system for the treatment and medication of immune checkpoint inhibitors, including an interpretation system for biomarkers related to immune checkpoint inhibitors and its construction method, a medication guidance adaptation method, a device, and a storage medium, wherein the construction method of the interpretation system includes: obtaining public Data resources, including biomarker information related to the treatment of tumor immune checkpoint inhibitors; screening and classification of public data resources to determine the key fields and attributes of the information to be entered into the interpretation system; immune checkpoint inhibition Classify the drug-related clinical evidence information; establish the structural framework of the interpretation system; enter the key field information into the corresponding field position of the interpretation system structural framework according to the unified standardized input rules. The invention solves the problem of inaccurate medication guidance due to scattered data, incomplete data collection, cumbersome query procedures, and no priority in drug recommendation for immune checkpoint inhibitors in the process of medication guidance for immune checkpoint inhibitors.

Description

technical field [0001] The present invention relates to the technical field of precision medicine, and in particular to a construction method of an immune checkpoint inhibitor treatment-related biomarker interpretation system, a medication guidance adaptation method for immune checkpoint inhibitor treatment, a device, and a storage medium. Background technique [0002] Tumor is a disease caused by the accumulation of genetic mutations, and there are a large number of different genetic mutations in tumor cells. Different tumors have different gene mutations, and the gene mutations of different individuals of the same tumor also have great differences. Precision medicine is an inevitable trend in the clinical treatment of tumors. Genetic testing is one of the important means of precision medicine, and targeted drug guidance is currently the most widely used direction for tumor genetic testing. However, authoritative data show that only about 37% of patients can find a potenti...

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a construction method of an immune checkpoint inhibitor treatment-related biomarker interpretation system, a method for guiding and adapting immune checkpoint inhibitor treatment medication, a device, and a storage medium to solve the problem of tumor immune checkpoint inhibitor treatment. In the process of medication guidance, there are scattered data, incomplete data collection, cumbersome query procedures, and no priority in the recommendation of immune checkpoint inhibitors, resulting in inaccurate medication guidance. At the same time, the machine automatically detects patients based on clinical information and immune-related biomarkers. The results (including gene variation, PD-L1 expression, TMB / bTMB, MSI / bMSI, TNB, HLA, etc.) will be issued as a test report as an important reference for medical decision-making, so as to quickly and accurately guide patients with immunotherapy

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