Carbohydrate composition for dialysis
A composition and compound technology, applied in the direction of carbohydrate active ingredients, drug combinations, hydroxyl compound active ingredients, etc., can solve the problem of not reporting low molecular weight solutions and icodextrin data and other issues
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example 1
[0304] Example 1: Industrial carbohydrate polymer preparation:
[0305] Starch milk was prepared from acid-fluidized commercial cornstarch. A starch suspension containing 20-50% solids was prepared by stirring until completely dissolved at 90°C. The solution was then cooled to 60°C and adjusted to pH 6-6.5 with citric acid.
[0306] For gelatinization, starch was treated with 0.1% thermostable alpha-amylase in the reaction medium and the reaction was terminated by heating between 88 and 92°C for 5 to 10 minutes.
[0307] For dextrinization, the pH was adjusted to 4 to 5, the concentration of amylase was increased to 0.3% and the reaction was allowed to proceed for a few more hours.
[0308] The final solution is separated in several steps including 30,000, 10,000, 5,000 Dalton separation devices such as membrane or ceramic filters.
[0309] Table 1 shows the composition of the physicochemical characteristics of two target glucan intermediate preparations or two PDF solution...
example 2
[0312] Example 2: Experimental Preparation
[0313] In this example, we produced polysaccharide formulations and final osmotically active compositions with Mw between 3.4 and 6.1 kD and Mn between 2 and 3.7 kD.
[0314] In all cases, this polymer fraction contains less than 1.5 wt% of polymers with molecular weights greater than 18 kD, and even less than 0.6 wt% of polymers with molecular weights greater than 40 kD.
[0315] Starting materials were obtained from commercially available of icodextrin. 80L batches at 3 to 4L / m as recommended by the supplier 2 and supply 0.5m with inlet pressure below 2.5 bar 2 pelicon 2 membrane. Successive steps of membrane cutoff of 100 kD, 30 kD, 10 kD and 5 kD were tested in different devices. Typically, each filtration step results in a retentate of about 5-10%, depending on the compositional concentration of the filtration solution. In this way, three intermediate carbohydrate polymer formulations, hereinafter referred to as soluti...
example 3
[0330] Example 3: Example of calculating Mw and Mn of different osmotically active compositions
[0331] Table 6: Calculated Mw and Mn of solution 3 (taking 5.75% saccharide polymer concentration as an example:
[0332]
[0333] For each fraction i, the MoI concentration is taken as the value (ni) for the number of compound molecules of this fraction, and the average molecular weight of this fraction is considered to be the molecular weight Mi of all molecules of this fraction. Then we can build the sum
[0334] Σ(ni)=27.5, Σ(ni*Mi)=57.5, Σ(ni*Mi) 2 )=200.8, and calculate
[0335] Mw=Σ(ni*Mi 2 ) / Σ(ni*Mi)=3.49kD, and
[0336] Mn=Σ(ni*Mi) / Σ(ni)=2.09kD.
[0337] Calculate Mw and Mn for maltose (1% solution):
[0338]
[0339] A fraction of 1% maltose corresponds to a single fraction with a molecular weight of 0.342 kD at a concentration of 29 M(ni), yielding
[0340] Σ(ni)=ni=29, Σ(ni*Mi)=niMi=10, and Σ(ni*Mi 2 )=niMi 2 = 3.42.
[0341] Calculate Mw and Mn for the...
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