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Compound anesthetic and preparation method thereof

An anesthetic and mixed extraction technology, applied in the field of anesthetics, can solve the problems of insignificant effect, complicated preparation process, and inappropriate application, and achieve the effects of promoting anesthetic effect, reducing production cost and relieving pain.

Inactive Publication Date: 2019-12-06
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method has various components, complicated preparation, and ineffective effect
[0007] Therefore, there is an urgent need to solve many problems such as poor effect, large side effects, complicated preparation process and inappropriate application in the prior art.

Method used

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  • Compound anesthetic and preparation method thereof
  • Compound anesthetic and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The composite anesthetic of this embodiment, the components include: 30% propofol, 3% methyl eugenol, 1% citric acid, 2% peppermint ice, 2.0% mixed extracts of basilica and red peony, 5% ethanol , 0.2% lecithin, the rest is water;

[0041] The preparation method of compound anesthetic comprises the following steps:

[0042] (1) Take the nine-layer wind and red peony with a weight ratio of 1:1, grind them, soak them in 3 times the volume of ethanol for 30 minutes, and reflux for 1 hour to obtain the alcohol extract 1 and the residue. Concentrate the alcohol extract to make the concentrated The volume of liquid is 1 / 6 times of original volume; Obtain ethanol extract 2;

[0043] (2) adding 3 times the mass of pulp residue into water, adding 0.5% citric acid based on the mass of the residue, heating to 90°C for extraction, and filtering to obtain water extract A;

[0044] (3) Water extract A is adjusted to pH value to 2 with acetic acid, add the chitosan of 0.1% water ext...

Embodiment 2

[0048] The composite anesthetic of this embodiment, the components include: 35% propofol, 2.5% methyl eugenol, 1.5% citric acid, 1.7% ice mint, 1.6% mixed extracts of basilica and red peony, 4.3% ethanol , 0.4% lecithin, the rest is water;

[0049] The preparation method of compound anesthetic comprises the following steps:

[0050](1) Grinding the nine-layer wind and red peony root with a weight ratio of 2:1, soaking in 5 times the volume of ethanol for 40 minutes, refluxing and extracting for 1.5 hours to obtain alcohol extract 1 and residue, and concentrating the alcohol extract to make The volume of the concentrated solution is 1 / 4 times of the original volume; the alcohol extract 2 is obtained;

[0051] (2) adding 4 times the mass of pulp residue to water, adding 1.0% citric acid based on the mass of the residue, heating to 80°C for extraction, and filtering to obtain water extract A;

[0052] (3) Water extract A is adjusted to pH value to 3 with acetic acid, add the ch...

Embodiment 3

[0056] The composite anesthetic of this embodiment, the components include: 40% propofol, 2% methyl eugenol, 2% citric acid, 1.5% peppermint ice, 1.0% mixed extract of basilica and red peony, 4% ethanol , 0.5% lecithin, the rest is water;

[0057] The preparation method of compound anesthetic comprises the following steps:

[0058] (1) Take the nine-layer wind and red peony with a weight ratio of 3:1, grind them, soak them in 6 times the volume of ethanol for 60 minutes, and extract them under reflux for 2 hours to obtain the alcohol extract 1 and the residue. Concentrate the alcohol extract to make the concentrated The volume of the liquid is 1 / 3 times of the original volume; the ethanol extract 2 is obtained;

[0059] (2) adding 5 times the mass of pulp residue into water, adding 1.5% citric acid based on the mass of the residue, heating to 60°C for extraction, and filtering to obtain water extract A;

[0060] (3) Water extract A is adjusted to pH value to 5 with acetic ac...

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Abstract

The invention belongs to the field of anesthetics, and particularly relates to a compound anesthetic and a preparation method thereof. The compound anesthetic is prepared from the raw materials: propofol, methyleugenol, citric acid, menthol ice, herba cladostachvdis, radix paeoniae rubra, ethanol, lecithin and water through extraction and mixing of effective ingredients. The compound anesthetic has good anesthetic and analgesic effects and is small in side effect, and the preparation method is simple and easy to implement.

Description

technical field [0001] The invention belongs to the field of anesthetics, and in particular relates to a compound anesthetic and a preparation method thereof. Background technique [0002] Anesthesia refers to the use of drugs or non-drug methods to reversibly block the nerve conduction at the site of its action, resulting in temporary loss of sensation in the local area. Nerve impulse conduction is weakened due to the decrease in the permeability of the nerve cell membrane to sodium ions. This change in membrane permeability reduces the depolarization level of the membrane and increases the excitatory threshold, and finally blocks the formation of the action potential of the nerve cell to achieve For the purpose of anesthesia, it is mostly used in surgery or medicine for the treatment of certain diseases. [0003] Most of the existing anesthetics have obvious side effects, such as local adverse reactions, increased symptoms of the central nervous system, cardiovascular eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/65A61K36/71A61K9/08A61K47/24A61P23/00A61K31/045A61K31/05A61K31/09
CPCA61K9/08A61K31/045A61K31/05A61K31/09A61K36/486A61K36/65A61K36/71A61K47/24A61P23/00A61K2300/00
Inventor 肖颖赵瑞敏
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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