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Doxofylline injection and preparation method thereof

A technology for doxofylline and injection, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve problems affecting drug quality and clinical drug safety, and achieve stable quality. , the effect of reducing production costs and low energy consumption

Inactive Publication Date: 2019-12-27
重庆健能医药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

The emergence of this phenomenon has greatly affected the quality of drugs and the safety of clinical medication.

Method used

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  • Doxofylline injection and preparation method thereof
  • Doxofylline injection and preparation method thereof
  • Doxofylline injection and preparation method thereof

Examples

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Embodiment 1

[0018] The present invention will be further described below in conjunction with specific experimental groups, but it should not be understood that the scope of the above subject of the present invention is limited to the following experimental groups. All technologies realized based on the above contents of the present invention belong to the scope of the present invention. The excipients in the following experimental groups can be replaced, or reduced or increased, with the same pharmaceutically acceptable excipients.

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Abstract

The invention discloses a doxofylline injection. Each 1000ml injection is prepared from the following components in grams: 100-200 g of doxofylline, 1-2 g of trehalose, 2-3 g of poloxamer and 0.5-1 gof citric acid. The doxofylline injection is good in stability. The invention further discloses a preparation method of the doxofylline injection. According to the preparation method, the process is simple, energy consumption is low, the production cost is lowered, and the prepared doxofylline injection has stable quality.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a doxofylline injection and a preparation method thereof. Background technique [0002] Doxofylline, a derivative of methylxanthine, is a bronchodilator that acts directly on the bronchi to relax bronchial smooth muscle. By inhibiting the action of phosphodiesterase in smooth muscle cells, it relaxes smooth muscle, thereby achieving the effect of inhibiting asthma. The general stability of the existing doxofylline injection is 2 years, and there are unstable situations such as discoloration. [0003] Doxofylline preparations have been widely used in the treatment of asthma and respiratory diseases since they were introduced into China in the 1990s. However, since the doxofylline preparation is a weakly alkaline preparation, there are certain defects in the physical and chemical stability of the preparation. Especially under the condition of small-volume i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/10A61K47/26A61K47/12A61K31/522A61P11/06A61P11/00
CPCA61K9/0019A61K9/08A61K31/522A61K47/10A61K47/12A61K47/26A61P11/00A61P11/06
Inventor 叶世春李于林李朝阳
Owner 重庆健能医药开发有限公司
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