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Medicine for preventing or reversing essential hypertension, type 2 diabetes or homologous diseases and construction method of animal model

A type 2 diabetes, homologous technology, applied in the medical field, can solve the problems of many causes, no drugs with common prevention or reversal effect, and no designated prevention or reversal of essential hypertension and type 2 diabetes at the same time

Inactive Publication Date: 2020-01-03
YICHANG CENT PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is difficult to directly screen and synthesize drugs corresponding to disease targets based on the homologous pathogenesis; moreover, due to the many causes of essential hypertension and type 2 diabetes and their homologous diseases, there is currently no drug that has a common prevention or reversal effect. Drugs, and clinical medication guidelines do not specify drugs and strategies that specifically prevent or reverse essential hypertension and type 2 diabetes and their homologous diseases

Method used

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  • Medicine for preventing or reversing essential hypertension, type 2 diabetes or homologous diseases and construction method of animal model
  • Medicine for preventing or reversing essential hypertension, type 2 diabetes or homologous diseases and construction method of animal model
  • Medicine for preventing or reversing essential hypertension, type 2 diabetes or homologous diseases and construction method of animal model

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Embodiment Construction

[0023] Below in conjunction with embodiment and accompanying drawing, further illustrate the present invention.

[0024] The preparation method of the raspberry alcohol extract provided by the invention and its sinapine thiocyanate content are determined as:

[0025] Extraction of AERS:

[0026] Laifuzi traditional Chinese medicine, coarsely crushed, accurately weighed 300mg, placed in a 50ml round bottom flask, added 30ml of 60% ethanol, refluxed twice for 2 hours each time, combined filtrate, filtered, took 20ml of filtrate, concentrated and frozen into powder, Obtain the alcoholic extract of radish seed.

[0027] Add 50% methanol to dissolve the radish seed alcohol extract powder, transfer it to a 5ml volumetric flask to constant volume, and filter it with a 0.45 μmol filter membrane to obtain the test solution.

[0028] HPLC determination, chromatographic conditions are: chromatographic column: Diamonsil TMC18 chromatographic column (250mm * 4.6mm, 5 μ m); Mobile phase: ...

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Abstract

The invention discloses a medicine for preventing or reversing essential hypertension, type 2 diabetes or homologous diseases and a construction method of an animal model. The screened medicine is alcohol extract of radish seeds (AERS), and the alcohol extract contains sinapine thiocyanate. The invention also relates to the construction method of the animal model with essential hypertension, type2 diabetes and homologous diseases. The alcohol extract of radish seeds presents dose dependence, increases animal feed consumption, inhibits weight and blood pressure increase and delays rise of blood fat level; fasting blood glucose, fasting blood insulin and insulin indexes are reduced; formation of early atherosclerosis is inhibited; and the liver weight is reduced, the normal liver form and hepatic cord arrangement are maintained, the formation of hepatic cell balloon-like vacuoles around liver central veins and inflammatory cell infiltration are inhibited, and the number of apoptosis ofhepatic cells is reduced. The medicine has good effects of resisting essential hypertension, type 2 diabetes and homologous diseases thereof.

Description

technical field [0001] The invention belongs to the medical field, in particular to a medicine for preventing or reversing essential hypertension, type 2 diabetes or homologous diseases and a method for constructing an animal model. Background technique [0002] Essential hypertension and type 2 diabetes are global chronic diseases, accounting for 17% of the world's total population. Worldwide, 425 million adults aged 20-79 have diabetes. At present, the number of adult hypertensive patients in my country has exceeded 270 million, and adult type 2 diabetes patients have exceeded 1 / 4 of the total number of adult patients in the world, reaching 114 million. And this number will show a rapid upward trend with the acceleration of human living standards, living habits and aging process. The main causes of death of essential hypertension and type 2 diabetes are coronary heart disease, stroke, renal failure, ketoacidosis, and can damage the eyes, heart, brain and other organs, se...

Claims

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Application Information

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IPC IPC(8): A61K36/31A61P9/12A61P3/10A61P3/06A61P3/04A61P1/16A61P9/10A01K67/02A61K49/00
CPCA01K67/02A01K2207/25A01K2227/105A01K2267/0362A01K2267/0375A61K36/31A61K49/0008A61P1/16A61P3/04A61P3/06A61P3/10A61P9/10A61P9/12
Inventor 李莉黄涵柽李馨欣
Owner YICHANG CENT PEOPLES HOSPITAL
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