Method for determining tobacco-specific nitrosamines in cigarette mainstream smoke by employing online two-dimensional chromatography-tandem mass spectrometry

A cigarette mainstream smoke and two-dimensional chromatography technology, applied in the field of chemical composition analysis in tobacco, can solve the problems of matrix interference, difficulty in accurate quantification, low nitrosamine content, etc.
CN110646536AInactive Publication Date: 2020-01-03SHANGHAI TOBACCO GRP CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI TOBACCO GRP CO LTD
Publication Date
2020-01-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for determining tobacco-specific nitrosamines in cigarette mainstream smoke by employing online two-dimensional chromatography-tandem mass spectrometry. The method comprises the steps of capturing and extracting cigarette mainstream smoke and then obtaining a sample solution; and carrying out qualitative and quantitative analysis on a nitrosamine component in the sample solution by adopting ultrahigh performance bonded-phased chromatography-liquid chromatography-mass spectrometry (UPCC-HPLC-MS / MS). The invention further provides an online two-dimensional chromatography-tandem mass spectrometry system for the tobacco-specific nitrosamines in the cigarette mainstream smoke and an application method of the online two-dimensional chromatography-tandem mass spectrometry system. The method for determining the tobacco-specific nitrosamines in the cigarette mainstream smoke by employing the online two-dimensional chromatography-tandem mass spectrometry providedby the invention has the advantages of being simple in operation, fast in detection and high in sensitivity and is suitable for routine analysis and detection of the tobacco-specific nitrosamines in the cigarette mainstream smoke, especially accurate quantification of traces of nitrosamines in medium and thin cigarette smoke samples.
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Description

technical field

[0001] The invention belongs to the technical field of chemical component analysis in tobacco, and relates to an online two-dimensional chromatography-tandem mass spectrometry method for determining tobacco-specific nitrosamines in mainstream smoke of cigarettes, in particular to the use of ultra-high performance convergence chromatography-liquid chromatography-mass spectrometry A combined method (UPCC-HPLC-MS / MS) for the determination of tobacco-specific nitrosamines in mainstream cigarette smoke. Background technique

[0002] Tobacco-specific nitrosamines (TSNAs) include 4-(N-methylnitrosamine)-1-(3-pyrazyl)-1-butanone (NNK), N-nitrosonornicotine (NNN ), N-nitrosopsine (NAB) and nitrosoanenicotine (NAT), are a class of tobacco-specific harmful substances in tobacco products and smoke, because of their strong carcinogenicity has always been Tobacco researchers at home and abroad are the focus of attention. Accurate determination of the content of tobacco-sp...

Claims

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