Traditional Chinese medicine hydrogel patch capable of treating chemotherapeutic phlebitis, and preparation method thereof

A technology of chemotherapeutic phlebitis and hydrogel patch, which is applied in the direction of medical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve inconvenient use, inaccurate dosage, and greasy skin To achieve better effect, comfortable application and suitable stickiness

Inactive Publication Date: 2020-01-07
SHANXI PROVINCE CHINESE MEDICINE RES INST
View PDF2 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides a traditional Chinese medicine hydrogel patch for treating chemotherapeutic phlebitis and its preparation in order to solve the technical problems of certain potential safety hazards, inconvenient use, inaccurate dosage, greasy skin, and difficulty in cleaning in the original compound Tengzhi ointment. method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Traditional Chinese medicine hydrogel patch capable of treating chemotherapeutic phlebitis, and preparation method thereof
  • Traditional Chinese medicine hydrogel patch capable of treating chemotherapeutic phlebitis, and preparation method thereof
  • Traditional Chinese medicine hydrogel patch capable of treating chemotherapeutic phlebitis, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: A traditional Chinese medicine hydrogel patch for treating chemotherapeutic phlebitis, which has the following preparation methods:

[0026] (1) First weigh 150 g of Sargentodoxa cuneata, 150 g of Angelica dahurica, 150 g of rhubarb, 250 g of Fritillaria vulgaris, 40 g of woody, 150 g of cork, 10 g of frankincense, 10 g of myrrh, 5 g of borneol, and menthol 4 g, of which frankincense, myrrh, borneol, and menthol are ground into fine powder for later use; add 8000 mL of 80% ethanol after mixing the rest of the drugs, soak for 0.5 h, heat and reflux for extraction 3 times, 1.5 h each time, filter and combine Extract the liquid three times, recover the ethanol under reduced pressure, and concentrate it into a thick ointment with a relative density of 1.1, frankincense, myrrh, borneol, and menthol crushed fine powder, and add it to the concentrated liquid to obtain the active ingredients of the raw material;

[0027] (2) Take 200g of the active ingredient of the bulk ...

Embodiment 2

[0064] Example 2: A traditional Chinese medicine hydrogel patch for the treatment of chemotherapeutic phlebitis, 250 g of Sargentodoxa cuneata, 250 g of Angelica dahurica, 250 g of rhubarb, 500 g of Fritillaria vulgaris, 50 g of woody, 250 g of cork, and 20 frankincense g. Myrrh 20 g, borneol 10 g, and menthol 10 g, of which frankincense, myrrh, borneol, and menthol are ground into fine powder for later use; the rest of the drugs are mixed and soaked in 8525 mL of 60% ethanol for 1 hour, heated and refluxed for extraction 2 After 1 hour each time, filter, combine the extracts twice, recover ethanol under reduced pressure, and concentrate it into a thick paste with a relative density of 1.15 to obtain the active components of the bulk drug.

[0065] (2) Take 400g of the active ingredient of the bulk drug obtained in step (1), add it to 4000g of glycerin, and mix thoroughly under the condition that the vacuum is not lower than -0.05MPa;

[0066] (3) Weigh 130g of polyacrylic acid / sod...

Embodiment 3

[0070] Example 3: A traditional Chinese medicine hydrogel patch for the treatment of chemotherapeutic phlebitis, 50 g of Sargentodoxa cuneata, 50 g of Angelica dahurica, 50 g of rhubarb, 150 g of Fritillaria vulgaris, 5 g of woody, 50 g of phellodendron chinense, and frankincense 5 g. Myrrh 5 g, borneol 1 g, and menthol 1 g, among which frankincense, myrrh, borneol, and menthol are ground into fine powder for later use; the rest of the medicine is mixed and soaked in 4,500 mL of 90% ethanol for 1.5 hours, heated and refluxed for extraction 2 times, 3 hours each time, filter, combine the extracts for 3 times, recover the ethanol under reduced pressure, and concentrate it into a thick paste with a relative density of 1.2 to obtain the active ingredient of the bulk drug.

[0071] (2) Take 80 g of the active ingredient of the bulk drug obtained in step (1), add it to 1000 g of glycerin, and mix thoroughly under the condition of a vacuum degree of not less than -0.05 MPa;

[0072] (3) W...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of traditional Chinese medicine preparation, and provides a traditional Chinese medicine hydrogel patch capable of treating chemotherapeutic phlebitis, anda preparation method thereof in order to solve the technical problems that an original compound Tengzhigao has certain potential safety hazards, is inconvenient in use, is inaccurate in dosages, causes skins to be greasy, is difficult in cleaning and the like. A medicine-carrying hydrogel matrix is prepared by mixing caulis sargentodoxae, radix angelicae dahurioae, bulbus fritillariae thunbergii,phellodendri chinensis cortex, radix rhei, radix aucklandiae, olibanum, myrrha, borneol and menthol at a certain ratio and adding skeleton materials, tackifier, humectant, cross-linking agents, crosslinking modifiers, filling agents, pH conditioning agents and distilled water, and then, the medicine-carrying hydrogel matrix is processed through steps of coating, cutting and standing to obtain thetraditional Chinese medicine hydrogel patch. The patch disclosed by the invention is pasted to chemotherapeutic phlebitis local skins, performs a targeted therapy function through the performing of the active ingredients of a long-acting slow release medicine, has the advantages of being convenient in use, comfortable in skin feelings, free from greasy feelings, free from irritation for skins, free from allergy and the like, and is an ideal external medicine preparation for treating the chemotherapeutic phlebitis.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparation, and specifically relates to a traditional Chinese medicine hydrogel patch for treating chemotherapeutic phlebitis. The invention also relates to a preparation method of the medicine. Background technique [0002] Chemotherapeutic phlebitis is a local complication that occurs after the patient has been infused with a blister or strong irritant liquid. The clinical manifestations are local pain, redness, swelling, hardening, and even vein strips. Its severity is related to the physical and chemical properties of the drug. Factors such as drug concentration, infusion time, infusion volume, and drug fluid extravasation are related. The American Society of Intravenous Nursing has divided phlebitis into five grades. The most serious standard is pain at the infusion site with redness or edema, which can be touched The length of the rope> 2.5cm, with pus flowing out. Becau...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/70A61K47/32A61P9/14A61K31/045
CPCA61K9/7023A61K31/045A61K36/185A61K36/232A61K36/285A61K36/324A61K36/328A61K36/708A61K36/756A61K36/8966A61K47/32A61K2236/333A61K2236/39A61K2236/51A61P9/14A61K2300/00
Inventor 王晞星郝淑兰吉海杰仝立国杨钤刘丽坤冯玛莉李宜放宋美卿张福鹏张小慧
Owner SHANXI PROVINCE CHINESE MEDICINE RES INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap