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Preparation method and application of a functionalized graphene-modified glassy carbon electrode

A glassy carbon electrode and graphene technology, applied in the direction of material electrochemical variables, material analysis through electromagnetic means, instruments, etc., can solve the problems of slow electron transfer rate, inaccurate detection results, easy adsorption of oxidation products, etc., and achieve good results. reproducible effect

Active Publication Date: 2021-12-28
SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The electrochemical sensor has ultra-high sensitivity and wide detection range for the detection of adrenaline, but the composite sensitive membrane has the disadvantages of slow electron transfer rate and easy adsorption of oxidation products when detecting adrenaline, resulting in inaccurate detection results The problem

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  • Preparation method and application of a functionalized graphene-modified glassy carbon electrode

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Experimental program
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Embodiment l

[0023] A preparation method for a functionalized graphene-modified glassy carbon electrode, comprising the steps of:

[0024] 1) Pretreatment of glassy carbon electrodes

[0025] The glassy carbon electrodes were sequentially coated with 1.0, 0.3, 0.05 μm Al 2 o 3 The powder was polished to a mirror surface, and then ultrasonically washed 3 times in twice distilled water and absolute ethanol, each time for 3 minutes, N 2 Dry and set aside for use to prepare a pretreated electrode.

[0026] 2) Activation of pretreatment electrodes

[0027] at 1.0 x 10 -3 mol / L K 3 [Fe(CN) 6 ] The pretreated electrode was electrochemically activated by cyclic voltammetry in the solution.

[0028] 3) Preparation of copper-doped γ-ureapropyltriethoxysilane functionalized graphene oxide

[0029] Weigh 1.00g of graphene oxide and dissolve it in 500mL of absolute ethanol, sonicate for 2 hours to obtain a graphene oxide solution, transfer it to a reaction kettle, and then add 0.15g of γ-ureapr...

Embodiment 2

[0033] A preparation method for a functionalized graphene-modified glassy carbon electrode, comprising the steps of:

[0034] 1) Pretreatment of glassy carbon electrodes

[0035] The glassy carbon electrodes were sequentially coated with 1.0, 0.3, 0.05 μm Al 2 o 3 The powder was polished to a mirror surface, and then ultrasonically washed 3 times in twice distilled water and absolute ethanol, each time for 3 minutes, N 2 Dry and set aside for use to prepare a pretreated electrode.

[0036] 2) Activation of pretreatment electrodes

[0037] at 1.0 x 10 -3 mol / L K 3 [Fe(CN) 6 ] The pretreated electrode was electrochemically activated by cyclic voltammetry in the solution.

[0038] 3) Preparation of nickel-doped γ-ureapropyltriethoxysilane functionalized graphene oxide

[0039]Weigh 1.00g of graphene oxide and dissolve it in 500mL of absolute ethanol, sonicate for 2 hours to obtain a graphene oxide solution, transfer it to a reaction kettle, and then add 0.18g of γ-ureapro...

Embodiment 3

[0043] A preparation method for a functionalized graphene-modified glassy carbon electrode, comprising the steps of:

[0044] 1) Pretreatment of glassy carbon electrodes

[0045] The glassy carbon electrodes were sequentially coated with 1.0, 0.3, 0.05 μm Al 2 o 3 The powder was polished to a mirror surface, and then ultrasonically washed 3 times in twice distilled water and absolute ethanol, each time for 3 minutes, N 2 Dry and set aside for use to prepare a pretreated electrode.

[0046] 2) Activation of pretreatment electrodes

[0047] at 1.0 x 10 -3 mol / L K 3 [Fe(CN) 6 ] The pretreated electrode was electrochemically activated by cyclic voltammetry in the solution.

[0048] 3) Preparation of iron-doped γ-ureapropyltriethoxysilane functionalized graphene oxide

[0049] Weigh 1.00g of graphene oxide and dissolve it in 500mL of absolute ethanol, sonicate for 2 hours to obtain a graphene oxide solution, transfer it to a reaction kettle, and then add 0.35g of γ-ureaprop...

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Abstract

The invention discloses a preparation method and application of a functionalized graphene-modified glassy carbon electrode. The preparation method comprises the steps of: after electrochemically activating the polished glassy carbon electrode, doping γ- Ureapropyltriethoxysilane functionalized graphene oxide is modified on its surface to obtain a functionalized graphene-modified glassy carbon electrode. Application of functionalized graphene-modified glassy carbon electrode to detect epinephrine concentration in electrochemical method. The invention utilizes the unique electrocatalytic properties of graphene oxide to solve the problems of slow detection response, narrow detection range and low sensitivity of traditional electrodes due to the disadvantages of slow electron transfer rate of adrenaline on bare electrodes and easy adsorption of oxidation products. The test method has good reproducibility and stability, and it is used for the determination of the concentration of epinephrine hydrochloride, and has the characteristics of rapidity, sensitivity and accuracy.

Description

technical field [0001] The invention belongs to the technical field of electrochemical method detection, and in particular relates to a preparation method and application of a functionalized graphene-modified glassy carbon electrode. Background technique [0002] Adrenaline is a catecholamine neurotransmitter, which plays a very important role in the normal activities of the human body, and the level of the content in body fluids will affect the health of the person. Therefore, the concentration detection of epinephrine and its metabolites is very important in drug analysis and clinical diagnosis. At present, a series of methods for detecting the concentration of epinephrine have been developed, such as high performance liquid chromatography, biosensor method, spectrophotometry, chemiluminescence method, fluorescence method, electrochemical method, capillary electrophoresis, etc. [0003] The essence of adrenaline oxidation reaction is electron transfer. Since the epinephr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/327G01N27/30
CPCG01N27/3277G01N27/3278G01N27/308
Inventor 李明田肖丽丽附青山杜鹃蒋琪邹睿夏凡琴
Owner SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING