Application of Sendeng-4 in tumor resistance

An anti-tumor, senden technology, applied in the application field of senden-4 in anti-tumor

Inactive Publication Date: 2020-01-14
内蒙古自治区国际蒙医医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The medicine is composed of 4 flavors, according to the order of the emperor, minister and assistant envoy, it is 15g of xanthus, 9g of toosendan, 3g of gardenia, and 3g of myrobalan. It has the function of clearing away heat and drying yellow water, and is used to treat gout, arthritis, edema, etc. diseases, there are few reports on the application of Senden-4 in anti-tumor

Method used

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  • Application of Sendeng-4 in tumor resistance
  • Application of Sendeng-4 in tumor resistance
  • Application of Sendeng-4 in tumor resistance

Examples

Experimental program
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Effect test

experiment example

[0011] Senden-4 extract preparation:

[0012] Take 250g of Asparagus lanceolata, 150g of Toosendan, 50g of Myrobalan, and 50g of Gardenia, grind them into fine powder, sieve, weigh and mix according to the above proportions, and get Sendeng 4 powder.

[0013] Take Sendeng 4 powder 100g, add 1000ml of 95% ethanol to soak for 24h, filter, the filtrate is rotary evaporated to remove ethanol, and add pure water to the concentrated solution to the volume before concentration to obtain the alcohol extract solution. Take another 100g of senden 4 powder, add 1000ml of pure water, soak for 24h, filter, and the filtrate is the water extraction solution. Equal volumes of the alcohol extract solution and the water extract solution are mixed to obtain an extract solution with a gallic acid (active ingredient) concentration of about 300 μg / ml.

[0014] The extract was adjusted to the corresponding concentration by adding distilled water.

[0015] Detection of cell proliferation by CCK-8 m...

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Abstract

The invention discloses application of Sendeng-4 in tumor resistance. Shown by in vitro study that the Sendeng-4 can effectively inhibit proliferation of melanoma cells A375, and the high-concentration Sendeng-4 can effectively induce cell apoptosis of the A375. In addition, the Sendeng-4 can effectively an autophagy level of the A375, which shows as transition of an autophagy marker protein LC3 from Type I to Type II along with increase of the concentration of a drug. In addition, the Sendeng-4 can inhibit phosphorylation activation of AKT and ERK signaling pathways to have obvious regulatingeffects on jnk and p38.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of senden-4 in antitumor. Background technique [0002] Mongolian Medicine Compound Sendeng-4 Decoction is an antirheumatic drug commonly used in Mongolian medicine clinics, and it is recorded in "Inner Mongolia Mongolian Patent Medicine Standard". The medicine is composed of 4 flavors, according to the order of the emperor, minister and assistant envoy, it is 15g of Asparagus, 9g of Toosendan, 3g of Gardenia, and 3g of Myrobalan. It has the function of clearing away heat and drying yellow water, and is used to treat gout, arthritis, edema, etc. diseases, there are few reports on the application of Senden-4 in anti-tumor. Contents of the invention [0003] The present invention intends to provide the application of Senden-4 in anti-tumor, so as to expand the use of Senden-4. [0004] In vitro studies have shown that Senden-4 can effectively inhibit the pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/77A61P35/00
CPCA61K36/185A61K36/58A61K36/744A61K36/77A61P35/00A61K2300/00
Inventor 都日娜赵鹏伟高耀星乌日娜杨丽敏
Owner 内蒙古自治区国际蒙医医院
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