A kind of adenine enhanced degradable soft tissue adhesive and its preparation and use method

A technology of adenine and soft tissue, applied in surgical adhesives, application, surgery, etc., can solve the problem of low adhesion strength, achieve high glass transition temperature, improve degradation performance, and excellent degradation performance

Active Publication Date: 2021-01-19
XI AN JIAOTONG UNIV
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of adenine enhanced degradable soft tissue adhesive and its preparation and use method, the present invention solves the low adhesion strength between polytrimethylene fumarate base material and soft tissue in the prior art, Key Issues Limiting Its Use in Soft Tissue Adhesives

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of adenine enhanced degradable soft tissue adhesive and its preparation and use method
  • A kind of adenine enhanced degradable soft tissue adhesive and its preparation and use method
  • A kind of adenine enhanced degradable soft tissue adhesive and its preparation and use method

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0047] Concrete preparation process comprises the following steps:

[0048] Step 1: PPF and PPF-DA are accurately weighed with a double bond ratio of 1:2 and placed in a round bottom flask containing 20mL-25mL of dichloromethane.

[0049] Step 2, add adenine with a mass ratio of 1%-7% of the total mass of PPF, PPF-DA and adenine to the mixed system obtained in step 1, and stir with a magnetic stirrer for 0.5h to completely dissolve PPF and PPF-DA , adenine is diffusely distributed, and mixture A is obtained.

[0050] Step 3, under vacuum condition, the dichloromethane solvent in the mixture A was removed by rotary evaporation. The rotary evaporation time is 0.67h-0.75h, the temperature is 30°C-35°C, the vacuum degree is not higher than 0.09MPa, and the mixture B is obtained. During the rotary evaporation, the temperature is gradually raised from 30°C to 35°C.

[0051] Step 4, adding the photoinitiator BAPO solution whose mass proportion is 1.5% of the total mass of the mixtu...

Embodiment 1

[0058] Put PPF and PPF-DA at a double bond ratio of 1:2 and a mass ratio of 1:2.08, accurately weigh 0.48g of PPF, and place 1g of PPF-DA in a round-bottomed flask containing 20mL of dichloromethane. Take adenine 0.0149g with an analytical balance and place it in the above-mentioned PPF and PPF-DA mixed system (the quality of adenine in this embodiment is 1% of the total mass of PPF, PPF-DA and adenine), place the round bottom flask Stir with a magnetic stirrer at a speed of 400r / min for 0.5h to completely dissolve PPF and PPF-DA, and adenine is dispersed in the mixed solution. Under vacuum conditions not higher than 0.09MPa, set the temperature of the rotary evaporator water bath to 30°C, keep it for 13 minutes, raise it to 33°C, keep it for 13 minutes, finally raise it to 35°C, keep it for 14 minutes, and rotate it together 0.67h to remove dichloromethane solvent. Using a pipette gun, pipette 224 μL of the 0.1 g / mL photoinitiator BAPO solution into the above-mentioned round...

Embodiment 2

[0060] Put PPF and PPF-DA at a double bond ratio of 1:2 and a mass ratio of 1:2.08, accurately weigh 0.48g of PPF, and place 1g of PPF-DA in a round-bottomed flask containing 20mL of dichloromethane. Take adenine 0.0458g with an analytical balance and place it in the above-mentioned PPF and PPF-DA mixed system (the quality of adenine in this embodiment is 3% of the total mass of PPF, PPF-DA and adenine), and place the round bottom flask Stir with a magnetic stirrer at a speed of 400r / min for 0.5h to completely dissolve PPF and PPF-DA, and adenine is dispersed in the mixed solution. Under vacuum conditions not higher than 0.09MPa, set the temperature of the rotary evaporator water bath to 30°C, keep it for 13 minutes, raise it to 33°C, keep it for 13 minutes, finally raise it to 35°C, keep it for 14 minutes, and rotate it together 0.67h to remove dichloromethane solvent. Using a pipette gun, pipette 229 μL of the 0.1 g / mL photoinitiator BAPO solution into the above-mentioned r...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to view more

Abstract

The invention discloses an adenine-reinforced degradable soft tissue adhesive as well as a preparation method and a use method thereof, and the preparation method comprises the following steps: step 1, putting PPF, PPF-DA and Adenine powder into a solvent, and uniformly stirring to obtain a mixture A; step 2, removing the solvent in the mixture A to obtain a mixture B; 3, adding a photoinitiator BAPO solution into the mixture B, and uniformly mixing the materials to obtain a mixture C; and step 4, removing the solvent in the mixture C to obtain the adenine-reinforced degradable soft tissue adhesive. When in use, ultraviolet light is adopted to carry out photocuring on the material. According to the invention, adenine is introduced into a poly propylene fumarate-based material in a dispersive distribution manner, and meanwhile, the bonding performance, degradation performance and biocompatibility of the material are improved. The problems that in the prior art, the adhesion strength between a PPF-based material and soft tissue is low, and application of the PPF-based material to a soft tissue adhesive is limited are solved.

Description

technical field [0001] The invention belongs to the technical field of medical soft tissue adhesives, in particular to an adenine-enhanced degradable soft tissue adhesive and its preparation and use methods. Background technique [0002] Compared with traditional surgical sutures, the emergence of medical adhesives has brought the wound closure method to a new level. It not only has ordinary adhesive properties, but also has specific biomedical functions, which can fundamentally improve treatment effect. After decades of research, various types of medical soft tissue adhesives, such as fibrin adhesives, BioGlue, cyanoacrylate adhesives, GRF adhesives, etc., have been used clinically, but the adhesive Insufficient bonding strength, risk of carrying viruses, poor degradation performance, and toxic degradation products have limited the further development of clinical applications of various soft tissue adhesives. In recent years, hydrogel-based adhesives applied to damaged ti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/06A61L24/00C08F299/04
CPCA61L24/0042A61L24/06C08F299/0428C08F299/0492C08L55/005
Inventor 郭大刚魏婷
Owner XI AN JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap