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Application of andrographolidume to preparation of health care product or medicine for preventing or/and treating muscle injury

An andrographolide, muscle damage technology, applied in the field of medicine, can solve problems such as reducing intracellular cholesterol content, increasing high-density lipoprotein cholesterol, etc., and achieves the effect of significantly reducing blood lipids, enhancing endurance, and improving muscle strength.

Active Publication Date: 2020-01-17
GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented inventor describes different ways to make medicine called probucolidone (PTL) without causing harmful symptoms such as heart attacks or blood clots when administered through other methods like injection. PTLS works differently from existing therapies than traditional ones due to its ability to stop bleeding quickly while still maintaining beneficial results over longer periods. Additionally, this technology provides technical benefits including improved efficacy against both acute and chronic conditions associated with excessive accumulation of lipids within tissues affected by arthritis, improving athletic performance, protecting organs from injury, promoting healing processes after surgery, enhancing body's immune response, increasing resistance to diabetes, lowering chances of developing cancer, and being effective at combating necrosis diseases related to oxalate radical production. Overall, these innovations provide potential medical applications beyond just create an antioxidative substance that prevents inflammation and cell deterioration induced by free radicals.

Problems solved by technology

This patented technical problem addressed in this patents relates to developing new treatments targeting various aspects associated with excessively calories eating habits including weight loss and exercise restriction without causing harmful side effect(cardiac disease). Statins were developed based on their beneficial properties against these issues, particularly reducing inflammation and improving heart functions during overweight conditions like those described above.

Method used

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  • Application of andrographolidume to preparation of health care product or medicine for preventing or/and treating muscle injury
  • Application of andrographolidume to preparation of health care product or medicine for preventing or/and treating muscle injury
  • Application of andrographolidume to preparation of health care product or medicine for preventing or/and treating muscle injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1 prepares andrographolide

[0058] After the medicinal material Andrographis paniculata (1kg) is crushed into coarse powder, add ethanol solution (mass concentration is 75%, usually 50-75%), heat and reflux extraction, the number of times of extraction is 2 times (usually 2-3 times), each time The volume of the ethanol solution during extraction is 5L (usually 5-20L), that is, the volume ratio of the volume of the ethanol solution to the Andrographis paniculata medicinal material is 5-20:1 during each extraction.

[0059] The extract is concentrated under reduced pressure until it has no alcohol smell, and the extract-concentrate is obtained. The temperature of the concentration under reduced pressure is 70°C, and the relative vacuum is -0.09~-0.075MPa. The weight of the extract-concentrate and the raw material The weight ratio of Andrographis paniculata is 1:1 (usually 1-5:1).

[0060] Add activated carbon to the extraction-concentrate, stir, filter after ...

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Abstract

The invention discloses application of andrographolidume to preparation of a health care product or medicine for preventing or/and treating muscle injury. Experiments prove that the andrographolidumehas the efficacy of overcoming the muscle injury such as muscle resistance and muscle strength reduction caused by hyperlipidemia; the muscle injury caused by the treatment by statins medicine, particularly muscle order action caused by untoward reaction such as rhabdomyolysis in the treatment process of hyperlipidemia diseases can be avoided, and the effects of enhancing the muscle resistance andinstant holding strength and protecting the muscle are achieved; and in addition, the andrographolidume also has the effects of regulating the blood lipid, reducing cholesterol, triglyceride and low-density lipoprotein cholesterol in the blood serum, increasing high-density lipoprotein cholesterol, reducing the cholesterol content in the cells, inhibiting the accumulation of the cholesterol between smooth muscle cell collagen and elastic fibers, preventing smooth muscle cell proliferation, and resisting atherosclerosis.

Description

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Claims

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Application Information

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Owner GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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