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Marker gene for predicting recurrence of stage II colorectal cancer and application thereof

A colorectal cancer and marker gene technology, applied in the field of bioinformatics, can solve problems such as inaccurate definitions and failure to consider tumor biological characteristics, and achieve the effect of reducing costs and variable dimensions

Active Publication Date: 2020-01-21
ZHEJIANG UNIV
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AI Technical Summary

Problems solved by technology

However, many current clinical studies have found that the definition of high-risk stage II is not accurate. Many high-risk stage II patients have no recurrence, while some general-risk stage II patients have recurrence and metastasis. This may be related to the traditional high-risk factors. The clinicopathological characteristics of the patient are not considered, and the biological characteristics of the tumor itself are not considered. However, the current gene chip technology and high-throughput sequencing technology can allow researchers to better mine the gene expression information of the tumor, and then reflect the biology of the tumor. feature

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  • Marker gene for predicting recurrence of stage II colorectal cancer and application thereof
  • Marker gene for predicting recurrence of stage II colorectal cancer and application thereof
  • Marker gene for predicting recurrence of stage II colorectal cancer and application thereof

Examples

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Embodiment 1

[0029] Example 1. Construction and verification of a tumor recurrence prediction model based on gene expression information in tumor tissues of patients with stage II colorectal cancer

[0030] (1) Obtain gene expression dataset

[0031] The gene expression data set is obtained by gene expression spectrum chip technology, that is, the mRNA expression values ​​of multiple individual samples are obtained, specifically:

[0032] The gene expression data set was obtained by searching the high-throughput gene expression database (https: / / www.ncbi.nlm.nih.gov / gds / ) of NCBI (National Center for Biotechnology Information), the search formula is: ("colorectal cancer "[All Fields]OR"colon cancer"[All Fields]OR"rectal cancer"[All Fields])AND"Expression profiling by array"[Filter], a total of 981 gene expression data sets (mRNA) were obtained, and according to the inclusion Criteria and exclusion criteria filter the data set.

[0033] The inclusion criteria of the data set are: (1) the ...

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Abstract

The invention discloses a marker gene for predicting recurrence of stage II colorectal cancer and application thereof. A public differentially expressed gene related to recurrence of a patient with stage II colorectal cancer is identified by adopting a gene chip meta-analysis technology, a model has an AUC value for predicting the risk for recurrence after 5 years of the patient with the stage IIcolorectal cancer being 0.806, and can be used for remarkably separating patients with high recurrence risk and low recurrence risk in a test set; and an Lasso Cox regression model is used to achievean effect of establishing a model and an effect of screening variable importance, so that the variable dimension of a model can be greatly reduced, the cost reduction for gene expression detection canbe favored, and popularization of the model in clinical application can be facilitated.

Description

[0001] (1) Technical field [0002] The present invention relates to the field of bioinformatics, in particular to the identification of public differentially expressed genes related to the recurrence of stage II colorectal cancer using gene chip meta-analysis technology, and the construction of a stage II colorectal cancer based on public differentially expressed genes and the Lasso Cox model Patient tumor recurrence prediction model. [0003] (2) Background technology [0004] Colorectal cancer is one of the most common malignant tumors in the world, ranking third in incidence and fourth in mortality among various malignant tumors. In recent years, with the improvement of the people's economic level and the change of lifestyle, the incidence of colorectal cancer in my country is gradually increasing and showing a younger trend. The number of new colorectal cancer patients increases by about 4% every year. [0005] The treatment of colorectal cancer is mainly surgical treatme...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/11G16B20/00G16B30/00
CPCC12Q1/6886C12Q2600/118C12Q2600/158G16B20/00G16B30/00
Inventor 丁克峰陆玮肖乾李军
Owner ZHEJIANG UNIV
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