Application of combination of dianhydrogalactitol and autophagy inhibitor in anti-melanoma drug preparation

Abstract

The invention belongs to the field of medicines, and discloses application of combination of dianhydrogalactitol and an autophagy inhibitor in anti-melanoma drug preparation. The anti-melanoma drug contains the dianhydrogalactitol and an autophagy inhibitor, wherein the autophagy inhibitor is selected from 3-MA; and the anti-melanoma drug is a compound drug prepared from the dianhydrogalactitol and the autophagy inhibitor. The autophagy inhibitor disclosed by the invention inhibits autophagy of melanoma cells induced by the dianhydrogalactitol; and the dianhydrogalactitol induces autophagy ofthe melanoma cells so as to counteract antagonism of melanoma to the treatment of the dianhydrogalactitol caused by autophagy, thereby significantly enhancing therapeutic effects of the dianhydrogalactitol on the melanoma. The combination of the dianhydrogalactitol and the autophagy inhibitor can very well inhibiting autophagy induced by single use of the dianhydrogalactitol, so that the combination of the dianhydrogalactitol and the autophagy inhibitor has significant curative effects on the melanoma; and moreover, the effects of the combination of the dianhydrogalactitol and the autophagy inhibitor is significantly better than effects of single use of the dianhydrogalactitol and the autophagy inhibitor. Thus, synergistic effects of the combination of the dianhydrogalactitol and the autophagy inhibitor are proven.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of Weikangol in combination with autophagy inhibitors in the preparation of anti-melanoma drugs. Background technique [0002] Melanoma originates from melanocytes and is the most malignant type of skin tumors. Metastatic melanoma reduces the five-year survival rate of patients from 98% to 17%. Usually, the matrix in the tumor microenvironment (tumor microenvironment, TME) is mainly composed of structural proteins and glycosaminoglycans, and the main component of the latter is sulfuric acid Heparan proteoglycans (HSPGs), in the TME, store a large number of biological factors (such as b-FGF, VEGF and TGF-β), and these factors are highly strategic in this war between the body and the tumor. However, the result is usually that heparanase-1 in the tumor microenvironment degrades HSPG, allowing a massive release of these biological factors that activate subsequent si...

AI Technical Summary

Problems solved by technology

[0003]At present, malignant tumors have become one of the most serious diseases that endanger human health, ranking second only to cardiovascular and cerebrovascular diseases, and the second leading cause of death. The World Health Organization The organization predicts that by 2020, there will be 20 million new cancer cases, of which 12 million will die, and most of them will occur in developing countries. These methods usually have serious side effects. Patients often have distant dissemination and tumor metastasis due to impaired immune function, which reduces the quality of life and shortens the survival period.

Therefore, in recent years, it has become a research hotspot to search for anti-tumor drugs with high efficiency and low toxicity from natural medicines. So far, a large number of chemical components obtained from plants such as paclitaxel, vincristine, and etoposide have been successfully developed and have been successfully applied to malignant tumors. In the first-line clinical treatment, Weikangol is a mutant strain of microorganism obtained from the bark of Yew yunnanensis. After fermentation and purification, a new type of simple So far, there has been no research on the effect of Viconol combined with autophagy inhibitors against melanoma

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