A method for separation and purification of antiallergic components in perilla leaves

A separation, purification and anti-allergic technology, applied in the direction of medical preparations containing active ingredients, allergic diseases, plant/algae/fungus/moss components, etc., can solve various complications, human troubles, safety hazards and other problems, Achieve the effects of short extraction time, simple and feasible method, and improved yield
CN110755476BActive Publication Date: 2022-01-25ZHONGBEI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHONGBEI UNIV
Publication Date
2022-01-25

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Abstract

The invention discloses a method for separating and purifying anti-allergic components in perilla leaves. Firstly, fresh perilla leaves are dried in the shade at room temperature, pulverized and sieved, soaked in a solvent, and extracted by enhanced mass transfer to obtain crude anti-allergic components of perilla. Then use thin-layer chromatography to determine the elution solvent, silica gel column chromatography and Sephadex column chromatography to purify the components of the anti-allergic crude extract of Perilla perilla, and the hyaluronidase inhibition rate can be as high as 89.76 % of perilla extract with high antiallergic activity. The separation and purification method provided by the invention has the advantages of simple operation, less time consumption, high yield, remarkable activity, good reproducibility of results, etc., and is suitable for the separation and purification of most plant active substances.
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Description

technical field

[0001] The invention relates to the technical field of plant extract production, in particular to a method for separating and purifying antiallergic components in perilla leaves. Background technique

[0002] Allergies are multiple common diseases. Although allergic diseases do not pose the most direct threat to human health like cancer and cardiovascular disease, they can cause long-term distress to humans, cause multiple complications, and may even be life-threatening. However, most chemically synthesized antiallergic drugs have potential toxicity and great potential safety hazards. Therefore, seeking a natural low-toxic antiallergic drug has become a research hotspot in the field of food and drug safety.

[0003] Perilla extract has anti-allergy, anti-oxidation, lowering blood lipid and blood pressure, protecting liver, inhibiting platelet aggregation, reducing thrombosis, anti-inflammation and protecting eyesight, etc., and has high research value. Hyal...

Claims

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