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Continuous brain slice image three-dimensional registration method based on shape constraint

A three-dimensional registration and brain image technology, which is applied in image analysis, image enhancement, image data processing, etc., can solve problems such as axial offset, and achieve the effect of solving axial offset

Active Publication Date: 2020-02-11
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

[0008] The purpose of the present invention is to provide a three-dimensional registration method of continuous brain slice images based on shape constraints to solve the problem of axial offset in the process of registering two-dimensional brain image sequences to three-dimensional brain atlases in the prior art

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  • Continuous brain slice image three-dimensional registration method based on shape constraint
  • Continuous brain slice image three-dimensional registration method based on shape constraint
  • Continuous brain slice image three-dimensional registration method based on shape constraint

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[0036] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0037] This embodiment specifically discloses a three-dimensional registration method for continuous brain slice images based on shape constraints. figure 1 , including the following steps:

[0038] S1, local shape correction:

[0039] S101. Select a picture with less damage from the two-dimensional brain image sequence to be registered as a starting picture.

[0040] S102. Starting from the starting picture, apply a linear registration algorithm to align two pictures adjacent to the starting picture to the starting picture one by one.

[0041] S103, then align ...

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Abstract

The invention provides a continuous brain slice image three-dimensional registration method based on shape constraint, and relates to the technical field of image registration. The method comprises the following steps: S1, aligning a to-be-registered two-dimensional brain image sequence to obtain a two-dimensional alignment sequence, and reconstructing the two-dimensional alignment sequence into an initial three-dimensional body; S2, linearly registering the standard brain atlas to the initial three-dimensional body to obtain a reference brain atlas, registering pictures of the two-dimensionalalignment sequence to tangent planes of corresponding positions in the reference brain atlas one by one to obtain a two-dimensional correction sequence, and reconstructing a corrected three-dimensional body; and S3, obtaining reverse deformation parameters of each pixel point in the corrected three-dimensional body, and performing spatial offset adjustment on the corrected three-dimensional bodyaccording to the reverse deformation parameters to obtain a refined three-dimensional body. The reference brain atlas is used as a constraint condition of the global shape, so that the correct shape of the real brain tissue is introduced into correction three-dimensional body reconstruction, and the problem of axial offset caused by lack of a spatial position relationship and global shape information in the prior art is solved.

Description

technical field [0001] The invention relates to the technical field of image registration, in particular to a three-dimensional registration method for continuous brain slice images based on shape constraints. Background technique [0002] Brain atlas is often referred to as the Baidu map in the fields of brain science and medicine. By matching neurobiological signals of interest, such as neuron projections and cerebrovascular branches, into a standard coordinate system, it can be used for clinical operations, precise drug delivery, and recognition. The work in different directions such as cognitive behavior research and brain functional circuit research provides accurate spatial positioning information. [0003] Building fine-grained brain atlases relies on image data with higher spatial resolution. With the advancement of micro-optical imaging technology, the currently acquired 3D image data sets can reach the micron resolution level in both lateral and axial directions, ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/38
CPCG06T7/38G06T2207/10012G06T2207/30016
Inventor 丰钊李安安张邹涛龚辉骆清铭
Owner HUAZHONG UNIV OF SCI & TECH
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