The invention relates to a method for preparing
chitosan oligosaccharide by utlizing ultrasonic-hydraulic collaborative
cavitation. The method is characterized by performing ultrasonic-hydraulic
cavitation degrading treatment on a
chitosan solution in an ultrasonic-hydraulic
cavitation device by adopting ultrasonic-hydraulic collaborative cavitation degrading, wherein the ultrasonic-hydraulic cavitation device comprises a constant-temperature water bath circulating water tank, a
storage tank, a pump, an ultrasonic-hydraulic cavitator, a pipeline for conveying the
chitosan solution, a pressure gauge and a valve. The technological process comprises the following steps: putting the chitosan solution into the
storage tank, stabilizing the temperature through the circulating water tank, conveying the chitosan solution to the ultrasonic-hydraulic cavitator through the pump for cavitation degrading, adjusting the
inlet pressure through the valve, and monitoring the pressure through the pressure gauge, wherein the chitosan solution subjected to cavitation degrading flows back into the
storage tank. Compared with the degrading rate of the existing hydraulic cavitation device (a Venturi tube) for preparing the
chitosan oligosaccharide, the degrading rate of the method disclosed by the invention is improved by at least 70 percent; the method has the characteristics of simplicity, convenience, feasibility, low
energy consumption, high efficiency and the like, and has the
advantage of large-scale industrial application.