33results about How to "Has large-scale industrial application" patented technology

The invention relates to a preparation method of oligochitosan. The oligochitosan is prepared through degradation of chitosan under hydraulic cavitation of chitosan solution. The preparation method comprises the following steps: dissolving the chitosan, carrying out hydraulic cavitation and degradation, adding alkali solution into the chitosan solution after degradation to adjust the pH, washing precipitates, carrying out vacuum drying and the like. The process of hydraulic cavitation and degradation comprises the following steps: placing the chitosan solution into a storage tank, maintaining a constant temperature through a circulating water tank, delivering the chitosan solution to a cavitation device for cavitation and degradation through a pump, adjusting the pressure of the upstream inlet with a valve V1, a valve V2, a valve V3 and a valve V4, restoring the pressure and flow of the downstream, monitoring the pressure and flow with a pressure gauge and a flow meter, making the solution after cavitation and degradation flow back to the storage tank, controlling the temperature to be 25-80 DEG C through the circulating water tank, and carrying out the circulating process in the hydraulic cavitation device for 0.5-20 hour(s) until the oligochitosan satisfies the requirements for the relative molecular mass. The method has the advantages of simple and convenient operation, low energy consumption, high efficiency and the like.

The invention discloses a method for preparing calcium carbide and a synthetic gas via a flameless oxidation heating method, and a calcium carbide reactor, and solves problems of influencing time and effect of calcium carbide reaction caused by uneven heat distribution of the calcium carbide and the synthetic gas prepared by a conventional method and non-uniform particle size of materials entering a reaction chamber. In the method, flameless combustion in the reaction chamber is realized by controlling oxygen content in a mixed gas passing into the reaction chamber; and problems of non-uniform particle size of materials in the reaction chamber is solved by designing feeding particle size at two feeding ports. The reactor enables heat distribution in the chamber to be more uniform through the improvement of oxygen burners of the reaction chamber and a vaporizing chamber. The method is simple in process, is safe and reliable, has more uniform heat distribution, high calcium carbide reaction efficiency and high calcium carbide purity, low loss to furnace walls, the content of the generated synthetic gas is over 7 times that a conventional electrothermal method, and at the same time, consumption rate of raw materials and fuels is low.

The invention discloses a method for producing high-purity (R)-(-)-3-hydroxybutyric acid by adopting an enzymatic method. Compared with a chemical method and a whole-cell fermentation method, the method disclosed by the invention has the advantages of mild reaction conditions, less waste liquid generation, high chemical purity of (R)-(-)-3-hydroxybutyric acid, single optical activity and the like.As the components of a culture medium for producing (R)-(-)-3-hydroxybutyric acid by the enzyme method are much simpler than those of the culture medium produced by a whole-cell fermentation method,the product separation cost is greatly reduced, and the purity is higher. According to the method, Diaphorobacter polyhydroxybutyrativorans bacteria are adopted to generate the PHB depolymerizing enzyme in a specific culture environment, and meanwhile, the PHB is used as a carbon source and an inducer for enzymolysis, so that the catalytic efficiency of the enzyme is extremely high.

The invention relates to a method for preparing oligochitosan through self-resonating cavitation. The method is characterized in that self-resonating cavitation degradation is adopted, that is, a chitosan solution is subjected to self-resonating cavitation degradation treatment in a self-resonating cavitation device; the self-resonating cavitation device comprises a thermostatic water-bath circulation water tank, a storage tank, a pump, a self-resonating cavitation device, a pipeline for conveying the chitosan solution, a pressure gauge and a valve; the technological process of self-resonating cavitation degradation is as follows: the chitosan solution is stored in the storage tank, subjected to thermostatic treatment by the circulation water tank and conveyed by the pump to the self-resonating cavitation device for cavitation degradation, the pressure of an inlet is adjusted by the valve, the pressure is monitored by the pressure gauge, and the chitosan solution subjected to cavitation degradation flows back to the storage tank. The degradation rate by using the method is at least 40% higher than that by using a hydrodynamic cavitation device (venturi tube) to prepare oligochitosan at present, and the method has the characteristics of simplicity, easiness, low energy consumption, high efficiency and the like and has the advantage of mass industrial application.

The invention provides a guide channel-shaped catalyst regular packing component in a plate-typed reaction rectifying tower, which is provided with a supporting frame, and a fixed leg is arranged below the bottom surface of the supporting frame; the top surface and the bottom surface of the supporting frame are uniformly welded with a plurality groups of metal sheets in the flowing direction of liquid on the tower plate so as to form an catalyst inserted-sheet channel; the distance of two adjacent groups of metal sheets is a flowing passage of liquid phase and gas phase on the guide tower plate; the catalyst inserted-sheet is filled with catalyst and is formed by a plurality of square prisms which have the cross section of rhombus and are made of metal wire meshes, hexagonal prisms with the cross section of shuttle shape or elliptical cylinders with the cross section of ellipse, in which the inserted-sheet are connected with each other from head to end; metal pressing strips and washer strips clamp the wire mesh through screws from two sides of the metal wire meshes and hang and button on the metal sheet on the top surface and the bottom surface so as to fix the inserted-sheet and form the guide channel-shaped catalyst structured packing component in the plate-typed reaction rectifying tower. The component solves the problem of low catalyst efficiency in the reaction rectifying tower, improves the separation efficiency of the plate-typed tower, has simple structure, and is convenient for processing, manufacture, installation and maintenance.

The invention provides a novel preparation method for a novel anti-hepatitis C drug-daklinza. The method comprises the steps of performing condensation on 4,4'-bis(2-chloracetyl)biphenyl as a raw material and N-(methoxycarbonyl)-L-valyl-L-proline at first and then performing ring-closing on a condensation product and ammonium acetate to obtain daklinza. The method has the advantages of cheap raw materials, few reaction steps, relatively short synthetic cycle and wide applicability.

The invention provides a corrosion-resistant treatment method for a metal welding line and relates to corrosion-resistant treatment for metal. According to the corrosion-resistant treatment method forthe metal welding line, a mussel adhesion protein/nanosized palladium composite membrane layer is constructed on the surface of a metal material after the pretreatment of the metal material to be treated, so that the corrosion resistance of the treated metal material is obviously improved; a mussel adhesion protein adopted is a natural environmentally-friendly material which can be extracted fromsea low-value mussels, the resource is rich, the cost is low and the industrialization prospects are good; the mussel adhesion protein adopted is good in anchoring strength and capable of complexingwith metal at the same time; the membrane layer adhesion is good and the prepared composite membrane layer has self repairing capacity at the same time; and the content of Pd adopted is very small andthe particle size of Pd in the prepared composite membrane layer is 100 nm in a diffuse distribution mode, so that the pitting corrosion resistance of the composite membrane layer is strengthened bythe electrochemical protection function of nanosized Pd and the bonding strength with the mussel adhesion protein is strengthened. The method is simple and practicable and strong in operability and has large-scale industrial application prospects.

The invention relates to a preparation process for ultrasonic reinforced supercritical CO2 extraction of tussah pupa oil. The process comprises the following steps of: (1) pre-treating raw materials, namely sorting, cleaning, sterilizing and freeze-drying tussah pupas and crushing the tussah pupas into tussah pupa powder by adopting a high-speed crusher; (2) putting the tussah pupa powder obtained in the step (1) into an extraction kettle, opening a CO2 gas bottle when the temperature reaches 40 to 50 DEG C to blow gas, adjusting the flow when the extraction pressure reaches 18 to 25MPa, and extracting the tussah pupa oil for 60 to 120 minutes at constant temperature under constant pressure; (3) emitting ultrasonic wave to the supercritical CO2 fluid in the extraction kettle by adopting a built-in insertion ultrasonic reinforcing mode in the step (2) to reinforce the tussah pupa oil extraction process; and (4) collecting the tussah pupa oil at the outlet of a separation kettle. The preparation process can remarkably improve the production efficiency, save the production cost and reduce the production energy consumption, and has large-scale industrialized application prospect. The invention also relates to an ultrasonic reinforced supercritical CO2 extraction system for the tussah pupa oil. The system has the predominant advantages of reasonable design, convenience for control, high production efficiency, low energy consumption and the like.

The invention provides a synthetic method of an intermediate (3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride of an anti-hepatitis C new drug Telaprevir. The method comprises the following steps: carrying out (S)-N-benzyl-1-phenylethylamine addition and camphorsulfonyloxaziridine oxidation of a cheap raw material t-butyl sorbate to obtain chiral amine, carrying out t-butyl deprotection, carrying out condensation with cyclopropylamine to obtain amide, and carrying out hydrogenation reduction benzyl-deprotection to form hydrochloride in order to obtain (3S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride. The method has the advantages of less reaction steps, short synthetic period and strong applicability.

The invention discloses a granular red mud absorbent used for processing a large quantity of low-concentration organic wastewater and heavy metal wastewater and a preparation method of the granular red mud absorbent, belonging to the technical field of environmental protection and water treatment. The prepared granular red mud absorbent comprises the following ingredients by weight: 60-70wt% of red mud dry basis, 2-10wt% of cement dry basis and 20-30wt% of water, the particle size range of the granular red mud absorbent is 0.05-5mm, the average pore size of the granular red mud absorbent is 22.13nm, the specific surface area of the granular red mud absorbent is 17.42-23.95m2/g, and the total pore volume of the granular red mud absorbent is 0.1325ml/g. The method is implemented as follows: mixing red mud containing certain water and dry cement uniformly, mixing and granulating by adopting a granulator, and then maintaining in the wet environment to finally obtain the granular red mud absorbent. The produced granular red mud absorbent is low in cost and good in absorbing effect, is cheap and practical, has good desorption capability and can be applied to the treatment process of organic wastewater or heavy metal wastewater.

The invention provides a polymer waterproof material, which comprises polymer colloid. The polymer colloid is obtained by mixing the following ingredients (by weight): 20-48 parts of hot melt adhesive, 1.7-5 parts of naphthenic oil, 10-20 parts of white cement, 30-60 parts of quartz sand and 0.3-1 part of green pigment. The polymer waterproof material also comprises a fetal membrane and an isolating membrane. The polymer colloid is uniformly dip-coated between the fetal membrane and the isolating membrane. The polymer waterproof material has excellent weatherability, peel strength and waterproofness, and can provide a skin-type waterproof barrier for building materials. Environmentally-friendly non-asphaltic base raw materials are adopted, and the ingredients are not complex. The preparation technology is simple, and production cost is low. The polymer waterproof material has economical and environmental-protection characteristics and has a wide prospect for large-scale industrial application.

The invention discloses a waterproof material comprising a tire film, a separator film and a polymer colloid. The polymer colloid is uniformly applied between the tire film and the separator film, andis obtained by mixing the following components by weight: 20 to 48 parts of a hot melt adhesive; 1.7 to 5 parts of naphthenic oil; 10 to 20 parts of white cement; 30 to 60 parts of quartz sand; 0.3 to 1 part of a green pigment; 1 to 5 parts of nano silica and 1 to 3 parts of nano-alumina. The waterproof material has excellent weather resistance, peeling strength and waterproof performance, can build a skin-type waterproof barrier for building materials, adopts an environmentally-friendly non-asphalt-based raw material, and has uncomplicated components, simple preparation process, low production cost, economical and environmental protection characteristic, and broad prospects for large-scale industrial application.

The invention provides acyltransferase for catalytic synthesis of simvastatin and a preparation method thereof. The acyltransferase has an amino acid sequence as shown in SEQ ID No. 2, and the site 161, site 163, site 180 and site 235 of the amino acid sequence undergo mutation so as to obtain a mutant. The enzyme activity of the novel acyltransferase in the invention is 12 times the enzyme activity of a wild enzyme; and the acyltransferase provided by the invention has the characteristics of low cost, short conversion time, simple operation, etc. and has good large-scale industrial application prospects.