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Sustained-release chemotherapy particles and preparation method and application thereof

A particle, sustained-release technology, applied in pharmaceutical formulations, microcapsules, medical preparations with non-active ingredients, etc., can solve problems such as high price, toxic side effects, dosage and cycle limitations, and achieve small differences and reduce toxic side effects. , easy-to-get effects

Active Publication Date: 2020-02-21
文黎明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Some chemotherapy drugs have serious toxic and side effects on the normal tissues of the body, so the dosage and cycle of the drug are limited
While other drugs with less toxic and side effects are often too expensive and unbearable for ordinary patients.

Method used

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  • Sustained-release chemotherapy particles and preparation method and application thereof
  • Sustained-release chemotherapy particles and preparation method and application thereof
  • Sustained-release chemotherapy particles and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A method for preparing slow-release chemotherapy microparticles provided by a preferred embodiment of the present invention comprises the following steps:

[0032] S1. Dissolve polycaprolactone in dichloromethane at a concentration of 0.1g / mL, then add cisplatin powder accounting for 10wt% of the total solution; carry out high-voltage electrospinning of the resulting solution to obtain nanofiber cores loaded with chemotherapeutic drugs Core; Among them, the high-voltage electrospinning conditions are: power supply voltage 14kV, the distance between the needle and the receiving substrate is 14cm, the feeding speed is 0.7mL / h for the outer layer, and 2.5mL / h for the inner layer;

[0033] S2. dissolving 1g of chitosan in 40mL of 2wt% acetic acid solution, then adding 18mL of 2wt% glutaraldehyde, stirring at a constant temperature of 50°C for 3h, and standing for 24h to obtain a chitosan hydrogel solution;

[0034] S3. Soak the nanofiber core loaded with chemotherapeutic dr...

Embodiment 2

[0037] A method for preparing slow-release chemotherapy microparticles provided by a preferred embodiment of the present invention comprises the following steps:

[0038] S1. Polycaprolactone is dissolved in dichloromethane, the concentration is 0.15g / mL, and then paclitaxel powder accounting for 20wt% of the total solution is added; the resulting solution is subjected to high-voltage electrospinning to obtain a nanofiber core loaded with chemotherapeutic drugs ; Among them, the high-voltage electrospinning conditions are: power supply voltage 14kV, the distance between the needle and the receiving substrate is 14cm, the feeding speed is 0.7mL / h for the outer layer, and 2.5mL / h for the inner layer;

[0039] S2. Dissolving 1g of chitosan in 42mL of 2wt% acetic acid solution, then adding 16mL of 2wt% glutaraldehyde, stirring at a constant temperature at 50°C for 3h, and standing for 24h to obtain a chitosan hydrogel solution;

[0040] S3. Soak the nanofiber cores loaded with che...

Embodiment 3

[0043] A method for preparing slow-release chemotherapy microparticles provided by a preferred embodiment of the present invention comprises the following steps:

[0044] S1. Dissolving polycaprolactone in dichloromethane at a concentration of 0.1g / mL, then adding 15wt% doxorubicin powder to the total solution; performing high-voltage electrospinning of the resulting solution to obtain nanofibers loaded with chemotherapeutic drugs Core; Among them, the high-voltage electrospinning conditions are: power supply voltage 14kV, the distance between the needle and the receiving substrate is 14cm, the feeding speed is 0.7mL / h for the outer layer, and 2.5mL / h for the inner layer;

[0045] S2. Dissolving 1g of chitosan in 38mL of 2wt% acetic acid solution, then adding 16mL of 2wt% glutaraldehyde, stirring at a constant temperature at 50°C for 3h, and standing for 24h to obtain a chitosan hydrogel solution;

[0046] S3. Soak the nanofiber core loaded with chemotherapeutic drugs obtained...

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Abstract

The invention discloses sustained-release chemotherapy particles and a preparation method and application thereof. The method comprises the following steps: preparing a core structure by using a coaxial electrostatic spinning method, soaking the core structure in chitosan gel, and finally preparing a shell structure by using a film dispersion method, thereby obtaining the sustained-release chemotherapy particles. The sustained-release chemotherapy particles prepared by the method have the characteristics that the preparation raw materials are easy to obtain, the regulation and control performance is strong, and the large-scale industrial production is easy. According to the prepared sustained-release chemotherapy particles, the sustained-release microspheres are used for chemotherapy, thesustained-release effect is good, the toxic and side effects on normal tissue can be reduced, and the anti-tumor effect can be continuously achieved within a long time.

Description

technical field [0001] The invention belongs to the technical field of chemotherapeutic drugs, and in particular relates to a slow-release chemotherapy microparticle and its preparation method and application. Background technique [0002] For patients with advanced cancer, they are generally weak in constitution, often lose indications for surgery, and cannot use strong radiotherapy and chemotherapy. The implantation of slow-release chemotherapy particles has a high local concentration in the lesion, and there is a slight local inflammatory reaction, without cell degeneration, necrosis and other adverse reactions. Expect. [0003] Some chemotherapy drugs have serious toxic and side effects on the normal tissues of the body, so the dosage and cycle of the drug are limited. While other drugs with less toxic and side effects are often too expensive for ordinary patients to bear. Contents of the invention [0004] The purpose of the present invention is to: aim at the defi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/36A61K47/34A61K45/00A61P35/00
CPCA61K9/5036A61K47/34A61K45/00A61P35/00
Inventor 文黎明李林艳杨亚玲曹耀丹
Owner 文黎明
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