Application of FLT3LG protein to preparation of lung adenocarcinoma postoperation and prognosis evaluation reagents or kits

A technology for prognosis assessment and lung adenocarcinoma, applied in the field of biomedicine, can solve the problems of lung cancer prognosis assessment that has not been reported in the literature, and achieve great social benefits and broad application prospects

Active Publication Date: 2020-02-25
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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Problems solved by technology

In addition, it has a certain effect on the prognosis assessment of malignant tumors such as osteosarcoma, but there is no literature report on the prognosis assessment of lung cancer

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  • Application of FLT3LG protein to preparation of lung adenocarcinoma postoperation and prognosis evaluation reagents or kits
  • Application of FLT3LG protein to preparation of lung adenocarcinoma postoperation and prognosis evaluation reagents or kits
  • Application of FLT3LG protein to preparation of lung adenocarcinoma postoperation and prognosis evaluation reagents or kits

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Embodiment Construction

[0041] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments, but should not be construed as a limitation of the present invention. The experimental methods in the following examples, unless otherwise specified, are conventional methods, and the materials, reagents, etc. used in the following examples, unless otherwise specified, can be obtained from commercial sources.

[0042]The invention provides an application of FLT3LG protein in the preparation of a postoperative prognosis evaluation kit for lung adenocarcinoma. Among them, "postoperative lung adenocarcinoma" refers to patients with lung adenocarcinoma who have received surgical treatment, and "prognosis assessment" refers to predicting the patient's survival time and recurrence and metastasis after surgical resection of the tumor. The amino acid sequence of the FLT3LG protein is shown in SEQ ID NO.1, and the nucleotide sequence encoding the FLT3LG...

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Abstract

The invention belongs to the technical field of biomedicine, and particularly discloses an application of an FLT3LG protein to preparation of lung adenocarcinoma postoperation and prognosis evaluationreagents or kits. According to the application, the FLT3LG protein is taken as a marker to detect lung adenocarcinoma tissue specimens through an immunohistochemical method and judge the prognosis ofthe lung adenocarcinoma patients; the FLT3LG protein has high expression in the lung adenocarcinoma and has low expression in para-carcinoma tissues; the expression level of the FLT3LG protein in thelung adenocarcinoma is related to the survival of the patients; and the high-expression patients are bad in prognosis and short in survival. The expression level of the FLT3LG protein is not only related to the total survival of the lung adenocarcinoma patients, but also related to the disease-free survival of the patients, and the patients, the FLT3LG protein of which has high expression, have recurrence or metastasis earlier; and serving as a lung adenocarcinoma postoperation and prognosis marker, the FLT3LG protein has a wide application prospect and a relatively large social benefit.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of a FLT3LG protein in the preparation of a postoperative prognosis assessment reagent or kit for lung adenocarcinoma. Background technique [0002] Lung cancer has become the malignant tumor with the highest morbidity and cancer mortality worldwide, seriously threatening human life and health. In my country, lung cancer has replaced liver cancer as the malignant tumor with the highest mortality rate, accounting for 22.7% of all malignant tumor deaths, and its morbidity and mortality are still rising rapidly. According to statistics, about 400,000 cases of lung cancer die every year in my country, and lung cancer has become the malignant tumor with the highest morbidity and mortality in my country. Although new progress has been made in the diagnosis and treatment of lung cancer with the development of technology in recent years, the overall 5-year...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/574
CPCG01N33/68G01N33/57423G01N33/57484G01N2333/47
Inventor 秦思达杨成成
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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