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Application of lysophosphatidylethanolamine 18: 1 in preparing drug for relieving and treating inflammatory bowel diseases

A technology of phosphatidylethanolamine and inflammatory bowel disease, which is applied in the field of medicine and can solve problems such as unclear etiology of inflammatory bowel disease

Inactive Publication Date: 2020-02-28
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, the etiology of inflammatory bowel disease is not clear and the effective means need further research

Method used

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  • Application of lysophosphatidylethanolamine 18: 1 in preparing drug for relieving and treating inflammatory bowel diseases
  • Application of lysophosphatidylethanolamine 18: 1 in preparing drug for relieving and treating inflammatory bowel diseases
  • Application of lysophosphatidylethanolamine 18: 1 in preparing drug for relieving and treating inflammatory bowel diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0022] Experiment 1: Pathogenic Escherichia coli infection mouse model, detection of lysophosphatidylethanolamine 18:1 content in feces of enteritis mice and patients

[0023] IExperimental material

[0024] As experimental animals, 6-week-old male C57BL / 6N mice, weighing 17±2 grams, were selected from the Institute of Model Animals, Nanjing University.

[0025] II Test Method and Results

[0026] 2.1 Animal experiments

[0027] (1). Transfer 16 C57BL / 6N mice into the biological isolation chamber;

[0028] (2). Oral administration of antibiotic mixed solution (Ampicillin 5mg per mouse, Neomycin 5mg per mouse, Vancomycin 5mg per mouse, Metronidazole 4mg per mouse), for one week continuously;

[0029] (3). Change drinking water to mixed antibiotic water for one week (Ampicillin 1g per liter, Neomycin 1g per liter, Vancomycin 0.5g per liter, Metronidazole 1g per liter);

[0030] (4). Replace with normal drinking water;

[0031] (5). The mice were randomly divided into 4 grou...

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Abstract

The invention belongs to the field of medicine and relates to an application of lysophosphatidylethanolamine 18: 1 in preparing a drug for relieving and treating inflammatory bowel diseases. The invention discloses that lysophosphatidylethanolamine 18: 1 alleviates or treats enteritis and inflammatory bowel diseases by increasing the stability of intestinal epithelial barrier. The lysophosphatidylethanolamine 18: 1 is an effective drug for the treatment of inflammatory bowel diseases.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to lysophosphatidylethanolamine 18:1, which relieves the occurrence and development of intestinal inflammation so as to prevent or treat enteritis and inflammatory bowel disease; in particular, lysophosphatidylethanolamine 18:1 increases the stability of the intestinal epithelial barrier , so as to alleviate or treat enteritis and inflammatory bowel disease. Background technique [0002] With the increasing abundance of production materials, people's diet is becoming more and more refined, and the incidence of inflammatory bowel disease (IBD) is increasing day by day. Worldwide, the annual incidence of IBD in North America and Western Europe exceeds 10 / 10 5 ; In China, the annual incidence of IBD increased from 0.3 / 10 in 1950 5 Up to 1.4 / 10 from 2002 5 , showing an increasing trend year by year. [0003] Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease involving the c...

Claims

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Application Information

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IPC IPC(8): A61K31/685A61P1/00A61P29/00
CPCA61K31/685A61P1/00A61P29/00
Inventor 高翔林兆宇周达远
Owner NANJING UNIV
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