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A kind of chloroquine antibacterial disinfectant and application thereof

A technology of disinfectant and chloroquine phosphate, which is applied in the fields of application, disinfectant, antibacterial, etc., can solve the problems of lack of research and reports on chloroquine disinfection and antibacterial cleaning products, and achieve the effect of broad application prospects

Active Publication Date: 2020-06-05
广州康健医学科技有限公司 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the antibacterial and disinfection needs for daily cleaning and care, there are no related products on the market at present, and there are no researches and reports on chloroquine-based disinfection and antibacterial cleaning products

Method used

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  • A kind of chloroquine antibacterial disinfectant and application thereof
  • A kind of chloroquine antibacterial disinfectant and application thereof
  • A kind of chloroquine antibacterial disinfectant and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 13

[0067] The bacteriostatic effect of embodiment 1 3% chloroquine phosphate liquid

[0068] 1. Make chloroquine phosphate into an in vitro disinfectant liquid with a mass concentration of 3%, the solvent is purified water, and the pH is adjusted to 7.0 with citric acid.

[0069] 2. Antibacterial effect test of chloroquine phosphate liquid

[0070] Add 20ml of the above medicinal liquid product to pH 7.0 buffer solution (the negative control does not add the test medicinal liquid, that is, the blank group) to fully dissolve it. Then add 1 mL, 0.5 mL, 0.25 mL, and 0.125 mL respectively to the medium corresponding to the corresponding strain, and invert the plate for culture. Pseudomonas aeruginosa, Candida albicans, Escherichia coli, and Staphylococcus aureus were recovered and diluted. When the bacterial concentration was 100 cfu / mL, the inoculation loop was inoculated with each medium, and the observation was started after 5 to 7 days of culture.

[0071] In vitro antibacteria...

Embodiment 2

[0076] Different concentrations of medicinal liquids were prepared with the method of Example 1, and the pH values ​​were all adjusted to 7.0. With the bacteriostatic test method of Example 1, the bacteriostatic effect of 0.25ml of each medicinal solution was tested. The results are shown in Table 2.

[0077] Table 2

[0078]

Embodiment 2

[0079] Example 2 Effect of pH value of medicinal liquid on antibacterial effect

[0080] With reference to the method of Example 1, 3% chloroquine phosphate liquids of different pH were prepared respectively, and the antibacterial effect of each liquid of 0.25ml was tested with the bacteriostatic test method of Example 1. The results are shown in Table 3. The results showed that acidic conditions were more conducive to the exertion of the bacteriostatic effect of chloroquine phosphate.

[0081] table 3

[0082]

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PUM

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Abstract

The invention discloses a chloroquine antibacterial disinfectant and application thereof. Chloroquine or a chloroquine derivative with the mass concentration of 0.1-5.0% is used as a main effective component, and the pH value is 4.0-7.0. Furthermore, plant extracts which are derived from natural plants and have a bactericidal effect can be supplemented, and an obvious synergistic effect is achieved on the bacteriostatic and antiviral effects of chloroquine. The liquid medicine has a certain cleaning and killing effect on various bacteria and viruses, especially on spreading and infection of coronavirus, HPV, HIV and other viruses and bacteria, and has a very good effect on prevention of oral cavity, home environment, exposed skin and other bacteria and virus susceptible parts. Moreover, chloroquine is developed into an external disinfection preparation and can be further developed into various sanitary disinfection products and old medicines for new use, compared with similar disinfection products, the external disinfection preparation can be orally taken and is small in harm, people can be more effectively protected against germs and viruses when the external disinfection preparation is sold on the market, and the external disinfection preparation is wide in application prospect.

Description

technical field [0001] The invention belongs to the technical field of antibacterial and disinfection products. More specifically, relate to a kind of antibacterial disinfectant containing chloroquine or chloroquine derivatives and application thereof. Background technique [0002] With the improvement of people's living standards and the deepening of understanding of microorganisms, the emphasis on personal hygiene in daily life has attracted more and more attention. [0003] Antibacterial cleaning products, such as mouthwash, hand sanitizer, disinfectant wipes, etc., play a good role in the daily protection of germs and viruses. However, almost all of the current similar products have only antibacterial effect and less antiviral effect. [0004] Chloroquine has long been used as a drug to prevent and treat Plasmodium infections. In vitro studies have found that high concentrations of chloroquine can inhibit and kill Cryptococcus in vitro (Research on the effect of chlor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4706A61K31/353A61K36/8962A61K36/815A61K36/28A61P31/02A61P31/04A61P31/12A61P31/14A61P31/18A01N43/42A01N43/16A01N65/42A01N65/38A01N65/12A01P1/00
CPCA01N43/16A01N43/42A01N65/00A01N65/12A01N65/38A01N65/42A61K31/353A61K31/4706A61K36/28A61K36/815A61K36/8962A61P31/02A61P31/04A61P31/10A61P31/12A61K2300/00
Inventor 王建瑜谢龙旭李相玲袁曼莉王婷胡博
Owner 广州康健医学科技有限公司
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