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Digital microfluidic dilution apparatus, systems, and related methods

A diluent and dilution ratio technology, applied in the field of electrode arrays, can solve problems such as increasing inaccuracy

Inactive Publication Date: 2020-03-31
ABBOTT LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Serial dilutions often produce large and difficult-to-manipulate droplets, thereby increasing the imprecision in the dilution process

Method used

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  • Digital microfluidic dilution apparatus, systems, and related methods
  • Digital microfluidic dilution apparatus, systems, and related methods
  • Digital microfluidic dilution apparatus, systems, and related methods

Examples

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manufacture example

[0090] After creating the first to eighth electrodes 302, 304, 306, 308, 310, 311, 312, 314, the electrode array 300 is coated with a hydrophobic and / or dielectric material so as to form via, for example, curing of the material such as Figure 3B Hydrophobic and / or dielectric layer 324 shown in . In some examples, electrode array 300 is formed from a portion of bottom substrate 316 . For example, electrode array 300 may be formed using a roll-to-roll assembly such that multiple electrode arrays are formed on bottom substrate 316 as bottom substrate 316 moves through the assembly. In such examples, after patterning the electrode design and / or depositing hydrophobic and / or dielectric material on the electrode array(s) 300, the bottom substrate 316 is cut into discrete sections, each comprising electrode array 300 . US Application Serial No. 14 / 687,398 discloses examples of fabrication of digital microfluidic chips and is hereby incorporated by reference in its entirety.

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Abstract

A digital microfluidic dilution apparatus, systems, and related methods are provided. Example methods, apparatus, systems for diluting samples are disclosed. An example method includes depositing a first fluid droplet on a first electrode of a plurality of electrodes. The first electrode has a first area. The first fluid droplet has a first volume associated with the first area. The example methodincludes depositing a second fluid droplet on a second electrode of the plurality of electrodes. The second electrode has a second area. The second fluid droplet has a second volume associated with the second area. The second volume is different than the first volume. The example method includes forming a combined droplet by selectively activating at least one of the first electrode or the secondelectrode to cause one of the first fluid droplet or the second fluid droplet to merge with the other of the first fluid droplet or the second fluid droplet.

Description

[0001] related application [0002] This patent claims the benefit of U.S. Provisional Patent Application No. 62 / 098,679 filed December 31, 2014 under 35 U.S.C. § 119(e), which is hereby incorporated by reference in its entirety. This application is an invention patent application No. PCT / US2015 / 067021 with the application date of December 21, 2015 and the priority date of December 21, 2014, with the title of invention "Digital Microfluidic Dilution Equipment, System and Related Methods" The divisional application of the original application entered the Chinese national phase and the national application number obtained was 201580077138.4. technical field [0003] The present disclosure relates generally to electrode arrays, and more particularly to digital microfluidic dilution devices, systems and related methods. Background technique [0004] Analytical devices typically require dilution of samples, such as biological fluids, within certain concentration levels, dependin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/502707B01L3/502792B01L2400/0427B01L2300/0645B01L2300/0861B01L2300/089
Inventor A.费希尔
Owner ABBOTT LAB INC